Universität zu Köln

Juenger, Stephanie Theresa, Timmermann, Beate and Pietsch, Torsten (2021). Pediatric ependymoma: an overview of a complex disease. Childs Nerv. Syst., 37 (8). S. 2451 - 2464. NEW YORK: SPRINGER. ISSN 1433-0350

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Abstract

Pediatric ependymomas comprise biologically distinct tumor entities with different (epi)genetics, age distribution and localization, as well as a different prognosis. Regarding risk stratification within these biologically defined entities, histopathological features still seem to be relevant. The mainstay of treatment is gross total resection (GTR) if possible, achieved with intraoperative monitoring and neuronavigation-and if necessary second surgery-followed by adjuvant radiation therapy. However, there is growing evidence that some ependymal tumors may be cured by surgery alone, while others relapse despite adjuvant treatment. To date, the role of chemotherapy is not clear. Current therapy achieves reasonable survival rates for the majority of ependymoma patients. The next challenge is to go beyond initial tumor control and use risk-adapted therapy to reduce secondary effect and therapy-induced morbidity for low-risk patients and to intensify treatment for high-risk patients. With identification of specific alterations, targeted therapy may represent an option for individualized treatment modalities in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Juenger, Stephanie Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Pietsch, Torsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-580481
DOI:	10.1007/s00381-021-05207-7
Journal or Publication Title:	Childs Nerv. Syst.
Volume:	37
Number:	8
Page Range:	S. 2451 - 2464
Date:	2021
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0350
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSTERIOR-FOSSA EPENDYMOMA; PROGRESSION-FREE SURVIVAL; SPINAL-CORD; MYXOPAPILLARY EPENDYMOMA; SUPRATENTORIAL EPENDYMOMAS; MOLECULAR CLASSIFICATION; INTRACRANIAL EPENDYMOMAS; PATHOLOGICAL ACTIVATION; RISK-STRATIFICATION; CHILDREN Multiple languages Clinical Neurology; Pediatrics; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58048