Universität zu Köln

Janssen, Ralf ORCID: 0000-0002-4026-4129, Pechmann, Matthias and Turetzek, Natascha (2021). A chelicerate Wnt gene expression atlas: novel insights into the complexity of arthropod Wnt-patterning. EvoDevo, 12 (1). LONDON: BMC. ISSN 2041-9139

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Abstract

The Wnt genes represent a large family of secreted glycoprotein ligands that date back to early animal evolution. Multiple duplication events generated a set of 13 Wnt families of which 12 are preserved in protostomes. Embryonic Wnt expression patterns (Wnt-patterning) are complex, representing the plentitude of functions these genes play during development. Here, we comprehensively investigated the embryonic expression patterns of Wnt genes from three species of spiders covering both main groups of true spiders, Haplogynae and Entelegynae, a mygalomorph species (tarantula), as well as a distantly related chelicerate outgroup species, the harvestman Phalangium opilio. All spiders possess the same ten classes of Wnt genes, but retained partially different sets of duplicated Wnt genes after whole genome duplication, some of which representing impressive examples of sub- and neo-functionalization. The harvestman, however, possesses a more complete set of 11 Wnt genes but with no duplicates. Our comprehensive data-analysis suggests a high degree of complexity and evolutionary flexibility of Wnt-patterning likely providing a firm network of mutational protection. We discuss the new data on Wnt gene expression in terms of their potential function in segmentation, posterior elongation, and appendage development and critically review previous research on these topics. We conclude that earlier research may have suffered from the absence of comprehensive gene expression data leading to partial misconceptions about the roles of Wnt genes in development and evolution.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Janssen, Ralf UNSPECIFIED orcid.org/0000-0002-4026-4129 UNSPECIFIED Pechmann, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Turetzek, Natascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-580711
DOI:	10.1186/s13227-021-00182-1
Journal or Publication Title:	EvoDevo
Volume:	12
Number:	1
Date:	2021
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	2041-9139
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLOMERIS-MARGINATA MYRIAPODA; T-BOX GENES; ACHAEARANEA-TEPIDARIORUM; POSTERIOR DEVELOPMENT; EMBRYONIC EXPRESSION; CUPIENNIUS-SALEI; GROWTH-ZONE; SEGMENTATION; EVOLUTION; WINGLESS Multiple languages Evolutionary Biology; Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58071