Universität zu Köln

Haeckel, Rainer, Wosniok, Werner and Streichert, Thomas (2021). Review of potentials and limitations of indirect approaches for estimating reference limits/intervals of quantitative procedures in laboratory medicine. J. Lab. Med., 45 (2). S. 35 - 54. BERLIN: WALTER DE GRUYTER GMBH. ISSN 2567-9449

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Abstract

Reference intervals (RIs) can be determined by direct and indirect procedures. Both approaches identify a reference population from which the RIs are defined. The crucial difference between direct and indirect methods is that direct methods select particular individuals after individual anamnesis and medical examination have confirmed the absence of pathological conditions. These individuals form a reference sub-population. Indirect methods select a reference subpopulation in which the individuals are not identified. They isolate a reference population from a mixed population of patients with pathological and non-pathological conditions by statistical reasoning. At present, the direct procedure internationally recommended is the gold standard. It has, however, the disadvantage of high expenses which cannot easily be afforded by most medical laboratories. Therefore, laboratories adopt RIs established by direct methods from external sources requiring a high responsibility for transference problems which are usually neglected by most laboratories. These difficulties can be overcome by indirect procedures which can easily be performed by most laboratories without causing economic problems. The present review focuses on indirect approaches. Various procedures are presented with their benefits and limitations. Preliminary simulation studies indicate that more recently developed concepts are superior to older approaches.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Haeckel, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Wosniok, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Streichert, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-580810
DOI:	10.1515/labmed-2020-0131
Journal or Publication Title:	J. Lab. Med.
Volume:	45
Number:	2
Page Range:	S. 35 - 54
Date:	2021
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	2567-9449
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REFERENCE INTERVAL ESTIMATION; DETERMINING REFERENCE LIMITS; HEALTHY-YOUNG MALES; NORMAL RANGES; REFERENCE VALUES; PATIENT DATA; URIC-ACID; DISTRIBUTIONS; RECOMMENDATION; BHATTACHARYA Multiple languages Medical Laboratory Technology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58081