Universität zu Köln

Baermann, J., Walter, H. L., Pikhovych, A., Endepols, H., Fink, G. R., Rueger, M. A. and Schroeter, M. (2021). An analysis of the CatWalk XT and a composite score to assess neurofunctional deficits after photothrombosis in mice. Neurosci. Lett., 751. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-7972

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Abstract

The purpose of this study was to evaluate CatWalk's capability for assessing the functional outcome after photothrombotic stroke affecting the motor cortex of mice. Mice were tested up to 21 days after photothrombosis or sham surgery using CatWalk, and a composite score assessing functional deficits (neuroscore). The neuroscore demonstrated deficits of the contralateral forelimb for more than two weeks after stroke. There were no asymmetric or coordinative dysfunctions of limbs detected by CatWalk. However, CatWalk data revealed impairment of locomotion speed and its depending parameters for one-week after stroke in strong correlation to the neuroscore. Data suggest that the composite neuroscore allows to more sensitively and precisely specify and quantify photothrombosis-induced hemisyndromes than CatWalk.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baermann, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, H. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pikhovych, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Endepols, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, G. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueger, M. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-581065
DOI:	10.1016/j.neulet.2021.135811
Journal or Publication Title:	Neurosci. Lett.
Volume:	751
Date:	2021
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-7972
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58106