Universität zu Köln

Hofmaier, Jan, Walter, Franziska, Hadi, Indrawati, Rottler, Maya, von Bestenbostel, Rieke, Dedes, George, Parodi, Katia, Niyazi, Maximilian, Belka, Claus and Kamp, Florian (2021). Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy. Phys. Imag. Radiat. Oncol., 20. S. 117 - 121. AMSTERDAM: ELSEVIER. ISSN 2405-6316

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Abstract

Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range uncertainty in a variance-based sensitivity analysis (SA). For ten patients with skull base meningioma, the mean calculation time to perform the SA including 1.6 x 10(4) dose recalculations was 59 min. For two patients in this dataset, IOV had a relevant impact on the estimated CTV D-95% uncertainty.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hofmaier, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Hadi, Indrawati UNSPECIFIED UNSPECIFIED UNSPECIFIED Rottler, Maya UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bestenbostel, Rieke UNSPECIFIED UNSPECIFIED UNSPECIFIED Dedes, George UNSPECIFIED UNSPECIFIED UNSPECIFIED Parodi, Katia UNSPECIFIED UNSPECIFIED UNSPECIFIED Niyazi, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Belka, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamp, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-581520
DOI:	10.1016/j.phro.2021.11.005
Journal or Publication Title:	Phys. Imag. Radiat. Oncol.
Volume:	20
Page Range:	S. 117 - 121
Date:	2021
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	2405-6316
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TARGET VOLUME DELINEATION; DOSIMETRIC IMPACT Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58152