Universität zu Köln

Wolf, Vinzent, Kuhnel, Anne ORCID: 0000-0003-3066-3801, Teckentrup, Vanessa ORCID: 0000-0002-9974-4557, Koenig, Julian and Kroemer, Nils B. (2021). Does transcutaneous auricular vagus nerve stimulation affect vagally mediated heart rate variability? A living and interactive Bayesian meta-analysis. Psychophysiology, 58 (11). HOBOKEN: WILEY. ISSN 1469-8986

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Abstract

Non-invasive brain stimulation techniques, such as transcutaneous auricular vagus nerve stimulation (taVNS), have considerable potential for clinical use. Beneficial effects of taVNS have been demonstrated on symptoms in patients with mental or neurological disorders as well as transdiagnostic dimensions, including mood and motivation. However, since taVNS research is still an emerging field, the underlying neurophysiological processes are not yet fully understood, and the replicability of findings on biomarkers of taVNS effects has been questioned. The objective of this analysis was to synthesize the current evidence concerning the effects of taVNS on vagally mediated heart rate variability (vmHRV), a candidate biomarker that has, so far, received most attention in the field. We performed a living Bayesian random effects meta-analysis. To keep the synthesis of evidence transparent and up to date as new studies are being published, we developed a Shiny web app that regularly incorporates new results and enables users to modify study selection criteria to evaluate the robustness of the inference across potential confounds. Our analysis focuses on 16 single-blind studies comparing taVNS versus sham in healthy participants. The meta-analysis provides strong evidence for the null hypothesis (g = 0.014, CIshortest = [-0.103, 0.132], BF01 = 24.678), indicating that acute taVNS does not alter vmHRV compared to sham. To conclude, there is no support for the hypothesis that vmHRV is a robust biomarker for acute taVNS. By increasing transparency and timeliness, the concept of living meta-analyses can lead to transformational benefits in emerging fields such as non-invasive brain stimulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wolf, Vinzent UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhnel, Anne UNSPECIFIED orcid.org/0000-0003-3066-3801 UNSPECIFIED Teckentrup, Vanessa UNSPECIFIED orcid.org/0000-0002-9974-4557 UNSPECIFIED Koenig, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroemer, Nils B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-581858
DOI:	10.1111/psyp.13933
Journal or Publication Title:	Psychophysiology
Volume:	58
Number:	11
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1469-8986
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ELECTRICAL-STIMULATION; FMRI EVIDENCE; BRAIN-STEM; PAIN; TONE; PROJECTIONS; EXTINCTION; SINOATRIAL; MOTILITY; ACCESS Multiple languages Psychology, Biological; Neurosciences; Physiology; Psychology; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58185