Universität zu Köln

van den Boogaard, Winnie M. C., van den Heuvel-Eibrink, Marry M., Hoeijmakers, Jan H. J. and Vermeij, Wilbert P. (2021). Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging. In: Annual Review of Cancer Biology-Series, S. 161 - 180. PALO ALTO: ANNUAL REVIEWS.

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Abstract

Dietary restriction (DR) is the most successful nutritional intervention for extending lifespan and preserving health in numerous species. Reducing food intake triggers a protective response that shifts energy resources from growth to maintenance and resilience mechanisms. This so-called survival response has been shown to particularly increase life- and health span and decrease DNA damage in DNA repair-deficient mice exhibiting accelerated aging. Accumulation of DNA damage is the main cause of aging, but also of cancer. Moreover, radiotherapies and most chemotherapies are based on damaging DNA, consistent with their ability to induce toxicity and accelerate aging. Since fasting and DR decrease DNA damage and its effects, nutritional preconditioning holds promise for improving (cancer) therapy and preventing short- and long-term side effects of anticancer treatments. This review provides an overview of the link between aging and cancer, highlights important preclinical studies applying such nutritional preconditioning, and summarizes the first clinical trials implementing nutritional preconditioning in cancer treatment.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code van den Boogaard, Winnie M. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED van den Heuvel-Eibrink, Marry M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeijmakers, Jan H. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vermeij, Wilbert P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-582411
DOI:	10.1146/annurev-cancerbio-060820-090737
Title of Book:	Annual Review of Cancer Biology-Series
Series Name:	Annu. Rev. Canc. Biol.
Volume:	5
Page Range:	S. 161 - 180
Date:	2021
Publisher:	ANNUAL REVIEWS
Place of Publication:	PALO ALTO
ISSN:	2472-3428
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TERM DIETARY RESTRICTION; CALORIC RESTRICTION; LIFE-SPAN; CHILDHOOD-CANCER; KETOGENIC DIET; BODY-COMPOSITION; GENOMIC INSTABILITY; COCKAYNE-SYNDROME; REPAIR; HEALTH Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58241