Kavsur, Refik, Spieker, Maximilian, Iliadis, Christos ORCID: 0000-0001-7655-8500, Metze, Clemens, Transier, Moritz, Tiyerili, Vedat, Horn, Patrick, Baldus, Stephan, Kelm, Malte ORCID: 0000-0003-0060-1052, Nickenig, Georg, Westenfeld, Ralf, Pfister, Roman and Becher, Marc Ulrich (2021). Mitral Regurgitation International Database (MIDA) Score Predicts Outcome in Patients With Heart Failure Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair. J. Am. Heart Assoc., 10 (13). HOBOKEN: WILEY. ISSN 2047-9980

Full text not available from this repository.

Abstract

Background Optimizing risk stratification in patients undergoing transcatheter mitral valve repair is an ongoing challenge. The Mitral Regurgitation International Database (MIDA) score represents a user-friendly mortality risk stratification tool that is validated on a large-scale registry of patients with degenerative mitral regurgitation (MR). We here assessed the potential benefit of the MIDA risk score for patients with functional or degenerative MR undergoing transcatheter mitral valve repair. Methods and Results In total, 680 patients undergoing MitraClip implantation were stratified according to MIDA score tertiles into a low (0-7), intermediate (8-9), and a high (10-12) MIDA score group. MR was assessed in follow-up echocardiograms in 416 patients at 323 +/- 169 days after transcatheter mitral valve repair. During 2-year follow-up, 8.2% (15/182) of patients with low, 21.3% (64/300) with intermediate, and 26.3% (52/198) with high MIDA score died (log-rank test P<0.001). Hazard of all-cause mortality increased by 13% (95% CI, 3%-25%) with every additional point of the MIDA score. Subanalysis of 431 patients with functional MR showed similar results. Furthermore, rates of a combined end point of mortality and hospitalization for heart failure were higher with increasing MIDA score (30% [54/182], 38% [113/300] and 48% [94/198], respectively, log-rank test P=0.001). Frequency of residual MR >= II at follow-up increased with increasing MIDA score group (33%, 44%, and 59%, respectively, P<0.001). Conclusions The MIDA mortality risk score maintains its predictive utility in patients undergoing transcatheter mitral valve repair, regardless of MR cause. Moreover, it was predictive of worse event-free survival regarding a combined end point of mortality and hospitalization for heart failure, and was associated with postprocedural residual MR >= II and MR recurrence.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kavsur, RefikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spieker, MaximilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iliadis, ChristosUNSPECIFIEDorcid.org/0000-0001-7655-8500UNSPECIFIED
Metze, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Transier, MoritzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tiyerili, VedatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horn, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldus, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kelm, MalteUNSPECIFIEDorcid.org/0000-0003-0060-1052UNSPECIFIED
Nickenig, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westenfeld, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becher, Marc UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-583869
DOI: 10.1161/JAHA.120.019548
Journal or Publication Title: J. Am. Heart Assoc.
Volume: 10
Number: 13
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 2047-9980
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EUROPEAN ASSOCIATION; MORTALITYMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/58386

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item