Universität zu Köln

Eming, Sabine A., Murray, Peter J. and Pearce, Edward J. (2021). Metabolic orchestration of the wound healing response. Cell Metab., 33 (9). S. 1726 - 1744. CAMBRIDGE: CELL PRESS. ISSN 1932-7420

Full text not available from this repository.

Abstract

Wound healing requires cooperation between different cell types, among which macrophages play a central role. In particular, inflammatory macrophages are engaged in the initial response to wounding, and alternatively activated macrophages are essential for wound closure and the resolution of tissue repair. The links between temporal activation-induced changes in the metabolism of such macrophages and the influence this has on their functional states, along with the realization that metabolites play both intrinsic and extrinsic roles in the cells that produce them, has focused attention on the metabolism of wound healing. Here, we discuss macrophage metabolism during distinct stages of normal healing and its related pathologic processes, such as during cancer and fibrosis. Further, we frame these insights in a broader context of the current understanding of macrophage metabolic reprogramming linked to cellular activation and function. Finally, we discuss parallels between the metabolism of macrophages and fibroblasts, the latter being a key stromal cell type in wound healing, and consider the importance of the metabolic interplay between different cell types in the wound microenvironment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eming, Sabine A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Murray, Peter J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pearce, Edward J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-584061
DOI:	10.1016/j.cmet.2021.07.017
Journal or Publication Title:	Cell Metab.
Volume:	33
Number:	9
Page Range:	S. 1726 - 1744
Date:	2021
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1932-7420
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL EFFECTOR FUNCTION; SUCCINATE-DEHYDROGENASE; STEM-CELLS; TISSUE-REPAIR; ALTERNATIVE ACTIVATION; TUMOR MICROENVIRONMENT; MACROPHAGE ACTIVATION; TRANSCRIPTION FACTOR; REPERFUSION INJURY; DIMETHYL FUMARATE Multiple languages Cell Biology; Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58406