Universität zu Köln

Rolles, Benjamin ORCID: 0000-0002-7393-861X, Wessels, Inga, Doukas, Panagiotis, Kotelis, Drosos, Rink, Lothar, Vieri, Margherita, Beier, Fabian, Jacobs, Michael and Gombert, Alexander (2021). Retrospective observational study evaluating zinc plasma level in patients undergoing thoracoabdominal aortic aneurysm repair and its correlation with outcome. Sci Rep, 11 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

Full text not available from this repository.

Abstract

Thoracoabdominal aortic aneurysm (TAAA) repair is related to a relevant morbidity and in-hospital mortality rate. In this retrospective observational single-center study including serum zinc levels of 33 patients we investigated the relationship between zinc and patients' outcome following TAAA repair. Six patients died during the hospital stay (18%). These patients showed significantly decreased zinc levels before the intervention (zinc levels before intervention: 60.09 mu g/dl [survivors] vs. 45.92 mu g/dl [non-survivors]). The post-interventional intensive care SOFA-score (Sepsis-related organ failure assessment) (at day 2) as well as the SAPS (Simplified Acute Physiology Score) (at day 2) showed higher score points in case of low pre-interventional zinc levels. No significant correlation between patient comorbidities and zinc level before intervention, except for peripheral arterial disease (PAD), which was significantly correlated to reduced baseline zinc levels, was observed. Septic shock, pneumonia and urinary tract infections were not associated to reduced zinc levels preoperatively as well as during therapy. Patients with adverse outcome after TAAA repair showed reduced pre-interventional zinc levels. We speculate that decreased zinc levels before intervention may be related to a poorer outcome because of poorer physical status as well as negatively altered perioperative inflammatory response.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rolles, Benjamin UNSPECIFIED orcid.org/0000-0002-7393-861X UNSPECIFIED Wessels, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Doukas, Panagiotis UNSPECIFIED UNSPECIFIED UNSPECIFIED Kotelis, Drosos UNSPECIFIED UNSPECIFIED UNSPECIFIED Rink, Lothar UNSPECIFIED UNSPECIFIED UNSPECIFIED Vieri, Margherita UNSPECIFIED UNSPECIFIED UNSPECIFIED Beier, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Jacobs, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Gombert, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-584130
DOI:	10.1038/s41598-021-03877-6
Journal or Publication Title:	Sci Rep
Volume:	11
Number:	1
Date:	2021
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language C-REACTIVE PROTEIN; INFLAMMATORY CYTOKINES; SUPPLEMENTATION; IMMUNE; SEPSIS Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58413