Universität zu Köln

Moestl, Stefan, Orter, Stefan, Hoffmann, Fabian, Bachler, Martin, Hametner, Bernhard, Wassertheurer, Siegfried, Rabineau, Jeremy, Mulder, Edwin, Johannes, Bernd, Jordan, Jens and Tank, Jens ORCID: 0000-0002-5672-1187 (2021). Limited Effect of 60-Days Strict Head Down Tilt Bed Rest on Vascular Aging. Front. Physiol., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-042X

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Abstract

Background Cardiovascular risk may be increased in astronauts after long term space flights based on biomarkers indicating premature vascular aging. We tested the hypothesis that 60 days of strict 6 degrees head down tilt bed rest (HDTBR), an established space analog, promotes vascular stiffening and that artificial gravity training ameliorates the response. Methods We studied 24 healthy participants (8 women, 24-55 years, BMI = 24.3 +/- 2.1 kg/m(2)) before and at the end of 60 days HDTBR. 16 subjects were assigned to daily artificial gravity. We applied echocardiography to measure stroke volume and isovolumetric contraction time (ICT), calculated aortic compliance (stroke volume/aortic pulse pressure), and assessed aortic distensibility by MRI. Furthermore, we measured brachial-femoral pulse wave velocity (bfPWV) and pulse wave arrival times (PAT) in different vascular beds by blood pressure cuffs and photoplethysmography. We corrected PAT for ICT (cPAT). Results In the pooled sample, diastolic blood pressure (+8 +/- 7 mmHg, p < 0.001), heart rate (+7 +/- 9 bpm, p = 0.002) and ICT (+8 +/- 13 ms, p = 0.036) increased during HDTBR. Stroke volume decreased by 14 +/- 15 ml (p = 0.001). bfPWV, aortic compliance, aortic distensibility and all cPAT remained unchanged. Aortic area tended to increase (p = 0.05). None of the parameters showed significant interaction between HDTBR and artificial gravity training. Conclusion 60 days HDTBR, while producing cardiovascular deconditioning and cephalad fluid shifts akin to weightlessness, did not worsen vascular stiffness. Artificial gravity training did not modulate the response.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moestl, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Orter, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachler, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hametner, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Wassertheurer, Siegfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Rabineau, Jeremy UNSPECIFIED UNSPECIFIED UNSPECIFIED Mulder, Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED Johannes, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Tank, Jens UNSPECIFIED orcid.org/0000-0002-5672-1187 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-584647
DOI:	10.3389/fphys.2021.685473
Journal or Publication Title:	Front. Physiol.
Volume:	12
Date:	2021
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-042X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SYSTOLIC-TIME INTERVALS; CARDIAC ATROPHY; DISTENSIBILITY; STIFFNESS; GRAVITY; DISEASE Multiple languages Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58464