Universität zu Köln

Wakileh, Gamal Anton, Ruf, Christian, Heidenreich, Axel, Dieckmann, Klaus-Peter, Lisson, Catharina, Prasad, Vikas ORCID: 0000-0003-2010-4117, Bolenz, Christian and Zengerling, Friedemann (2022). Contemporary options and future perspectives: three examples highlighting the challenges in testicular cancer imaging. World J. Urol., 40 (2). S. 307 - 316. NEW YORK: SPRINGER. ISSN 1433-8726

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Abstract

Purpose One of the main issues in testicular germ cell tumors (TGCTs) management is to reduce the necessary amount of treatment to achieve cure. Excess treatment burden may arise from late diagnosis of the primary as well as from false positive or negative staging results. Correct imaging is of paramount importance for successful management of TGCT. The aim of this review is to point out the current state of the art as well as innovative developments in TGCT imaging on the basis of three common challenging clinical situations. Methods A selective literature search was performed in PubMed, Medline as well as in recent conference proceedings. Results Regarding small testicular lesions, recent studies using elastography, contrast-enhanced ultrasound or magnetic resonance imaging (MRI) showed promising data for differentiation between benign and malignant histology. For borderline enlarged lymph nodes FDG-PET-CT performance is unsatisfactory, promising new techniques as lymphotropic nanoparticle-enhanced MRI is the subject of research in this field. Regarding the assessment of postchemotherapeutic residual masses, the use of conventional computerized tomography (CT) together with serum tumor markers is still the standard of care. To avoid overtreatment in this setting, new imaging modalities like diffusion-weighted MRI and radiomics are currently under investigation. For follow-up of clinical stage I TGCTs, the use of MRI is non-inferior to CT while omitting radiation exposure. Conclusion Further efforts should be made to refine imaging for TGCT patients, which is of high relevance for the guidance of treatment decisions as well as the associated treatment burdens and oncological outcomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wakileh, Gamal Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruf, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Dieckmann, Klaus-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Lisson, Catharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Prasad, Vikas UNSPECIFIED orcid.org/0000-0003-2010-4117 UNSPECIFIED Bolenz, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Zengerling, Friedemann UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-585342
DOI:	10.1007/s00345-021-03856-6
Journal or Publication Title:	World J. Urol.
Volume:	40
Number:	2
Page Range:	S. 307 - 316
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-8726
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GERM-CELL TUMORS; POSITRON-EMISSION-TOMOGRAPHY; APPARENT DIFFUSION-COEFFICIENT; STAGE-I; FDG-PET; MANAGEMENT; DIAGNOSIS; SEMINOMA; BENIGN; MRI Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58534