Universität zu Köln

Klein, M., Wermker, K., Hallermann, C., Pannier, F., Holzle, F. and Modabber, A. (2021). Immune checkpoint analysis in lip cancer. J. Cranio-MaxilloFac. Surg., 49 (10). S. 950 - 959. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1878-4119

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Abstract

The aim of this study was to establish whether PD-L1, PD-1, and markers of the tumor microenvironment (CD4, CD8, FOXP3) could have a prognostic value in squamous cell carcinoma of the lip (LSCC). In patients with histologically proven LSCC, tumor specimens were stained using immunohistochemistry (for PD-1, PD-L1, CD4, CD8, and FOXP3) on paraffin-embedded tissues. Patients with (N+) and without (N-) nodal metastasis were stratified and matched to each other according to prognostically relevant clinicopathological parameters. 58 patients (29 N+ and 29 N-) were included. PD-L1 expression was positive (>1%) in 56.1% (n = 33) of all LSCC cases, but its expression did not differ significantly between metastasis groups (65.5% in N+ versus 48.3% in N-; p = 0.144). Nodal disseminated LSCC showed a tendency for higher PD-L1 expression. None of the analyzed markers showed significant correlation with the risk for nodal disease, or revealed significant prognostic value. Due to their significant expression, PD-L1 and PD-1 are potential targets for checkpoint inhibitor therapy in LSCC. Their expression should be analyzed in advanced and metastasized LSCC cases. (c) 2021 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klein, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wermker, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallermann, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pannier, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holzle, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Modabber, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-587104
DOI:	10.1016/j.jcms.2021.05.007
Journal or Publication Title:	J. Cranio-MaxilloFac. Surg.
Volume:	49
Number:	10
Page Range:	S. 950 - 959
Date:	2021
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1878-4119
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; LIGAND 1 EXPRESSION; PD-L1 EXPRESSION; NODAL METASTASIS; POOR-PROGNOSIS; ORAL-CAVITY; HEAD; PATHWAY; PEMBROLIZUMAB; RECURRENT Multiple languages Dentistry, Oral Surgery & Medicine; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58710