Universität zu Köln

Rueb, Alina M., Tsakmaklis, Anastasia, Graefe, Stefanie K., Simon, Marie-Christine ORCID: 0000-0001-6625-1265, Vehreschild, Maria J. G. T. and Wuethrich, Irene (2021). Biomarkers of human gut microbiota diversity and dysbiosis. Biomark. Med., 15 (2). S. 137 - 149. LONDON: FUTURE MEDICINE LTD. ISSN 1752-0371

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Abstract

The association of gut microbiota dysbiosis with various human diseases is being substantiated with increasing evidence. Metabolites derived from both, microbiota and the human host play a central role in disease susceptibility and disease progression by extensively modulating host physiology and metabolism. Several of these metabolites have the potential to serve as diagnostic biomarkers for monitoring disease states in conjunction with intestinal microbiota dysbiosis. In this narrative review we evaluate the potential of trimethylamine-N-oxide, short-chain fatty acids, 3-indoxyl sulfate, p-cresyl sulfate, secondary bile acids, hippurate, human beta-defensin-2, chromogranin A, secreted immunoglobulins and zonulin to serve as biomarkers for metabolite profiling and diagnostic suitability for dysbiosis and disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rueb, Alina M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tsakmaklis, Anastasia UNSPECIFIED UNSPECIFIED UNSPECIFIED Graefe, Stefanie K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Marie-Christine UNSPECIFIED orcid.org/0000-0001-6625-1265 UNSPECIFIED Vehreschild, Maria J. G. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wuethrich, Irene UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-587900
DOI:	10.2217/bmm-2020-0353
Journal or Publication Title:	Biomark. Med.
Volume:	15
Number:	2
Page Range:	S. 137 - 149
Date:	2021
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1752-0371
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; BILE-ACIDS; HIPPURATE HYDROLYSIS; EPITHELIAL-CELLS; INDOXYL SULFATE; METABOLISM; ZONULIN; IGA; BETA-DEFENSIN-2 Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58790