Universität zu Köln

Zimbelmann, Michael, Neppert, Birte, Piria, Roya, Babst, Neele, Ponto, Katharina A., Grisanti, Salvatore, Heindl, Ludwig M. and Kakkassery, Vinodh (2021). Treatment and management of orbital tumors. Ophthalmologe, 118 (10). S. 1004 - 1012. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0423

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Abstract

Background There are various options for the conservative treatment of the most frequent orbital tumors. These can delay, complement or be superior to the surgical approach, which is often prone to complications. Objective This article gives a summary of the possible treatment options for the most common orbital tumors in childhood and adulthood. Methods A literature search was carried out and the possible treatment pathways are presented. Results 1. Frequent orbital tumors in childhood: a systemic treatment with noncardioselective beta blockers is the primary treatment for capillary orbital hemangiomas. In cases of no response, steroids, interferon alpha or cyclophosphamide are treatment options. Observation is a possible option for smaller dermoid cysts, in cases of progression excision can become necessary. Symptomatic optic nerve gliomas can also be observed and in cases of progression treated with chemotherapy, mTOR/MEK inhibitors or radiotherapy (children > 5 years). Rhabdomyosarcomas are biopsied and subsequently treated by radiotherapy and chemotherapy. 2. Frequent orbital tumors in adulthood: asymptomatic cases of cavernous hemangiomas of the orbit can just be observed. Symptomatic hemangiomas can be surgically excised or treated with radiotherapy. For meningiomas of the optic nerve sheath radiotherapy is a very effective treatment. Surgical excision should be reserved for cases with no prognosis of visual acuity. There is also the option to treat with antiprogesterone. Orbital lymphomas with purely orbital involvement can be treated with radiotherapy, chemotherapy or the application of rituximab. Conclusion There are now very effective conservative treatment options for many orbital tumors. In some cases a surgical procedure can be avoided and a good visual function can be retained.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zimbelmann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Neppert, Birte UNSPECIFIED UNSPECIFIED UNSPECIFIED Piria, Roya UNSPECIFIED UNSPECIFIED UNSPECIFIED Babst, Neele UNSPECIFIED UNSPECIFIED UNSPECIFIED Ponto, Katharina A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grisanti, Salvatore UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kakkassery, Vinodh UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-588833
DOI:	10.1007/s00347-021-01471-9
Journal or Publication Title:	Ophthalmologe
Volume:	118
Number:	10
Page Range:	S. 1004 - 1012
Date:	2021
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0423
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTIC-NERVE SHEATH; ORAL PROPRANOLOL; MULTIDISCIPLINARY TREATMENT; INTRALESIONAL PROPRANOLOL; CAPILLARY HEMANGIOMA; PATHWAY GLIOMAS; RHABDOMYOSARCOMA; MENINGIOMAS; CARBOPLATIN; CHILDHOOD Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58883