Universität zu Köln

Eleni, Pappa, Georgia, Panagiotaropoulou, Constantine, Potagas, Efstratios, Karavasilis, Georgios, Velonakis, Nikolaos, Kelekis, Christoph, Klein and Nikolaos, Smyrnis (2021). Functional brain imaging of speeded decision processing in Parkinson's disease and comparison with Schizophrenia. Psychiatry Res. Neuroimaging, 314. CLARE: ELSEVIER IRELAND LTD. ISSN 1872-7506

Full text not available from this repository.

Abstract

This study examined whether Parkinson's disease (PD1) and schizophrenia (SCZ2) share a hypo dopaminergic dysfunction of the prefrontal cortex leading to cognitive impairments in decision processing. 24 medicated PD patients and 28 matched controls performed the Eriksen flanker two-choice reaction time (RT3) task while brain activity was measured throughout, using functional Magnetic Resonance Imaging (fMRI4). Results were directly compared to those of 30 SCZ patients and 30 matched controls. Significant differences between SCZ and PD were found, through directly comparing the z-score deviations from healthy controls across all behavioral measures, where only SCZ patients showed deviances from controls. Similarly a direct comparison of z-score activation deviations from controls indicated significant differences in prefrontal and cingulate cortical activation between SCZ and PD, where only SCZ patients showed hypo-activation of these areas compared to controls. The hypoactivation of the dorsolateral prefrontal cortex was related to larger RT variability (ex-Gaussian tau) in SCZ but not PD patients. Overall, the concluding evidence does not support a shared neural substrate of cognitive dysfunction, since the deficit in speeded decision processing and the related cortical hypo-activation observed in SCZ were absent in PD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eleni, Pappa UNSPECIFIED UNSPECIFIED UNSPECIFIED Georgia, Panagiotaropoulou UNSPECIFIED UNSPECIFIED UNSPECIFIED Constantine, Potagas UNSPECIFIED UNSPECIFIED UNSPECIFIED Efstratios, Karavasilis UNSPECIFIED UNSPECIFIED UNSPECIFIED Georgios, Velonakis UNSPECIFIED UNSPECIFIED UNSPECIFIED Nikolaos, Kelekis UNSPECIFIED UNSPECIFIED UNSPECIFIED Christoph, Klein UNSPECIFIED UNSPECIFIED UNSPECIFIED Nikolaos, Smyrnis UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-588894
DOI:	10.1016/j.pscychresns.2021.111312
Journal or Publication Title:	Psychiatry Res. Neuroimaging
Volume:	314
Date:	2021
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1872-7506
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REACTION-TIME; INTRAINDIVIDUAL VARIABILITY; ALZHEIMERS-DISEASE; BASAL GANGLIA; INTERFERENCE; ATTENTION; COMPATIBILITY; PERFORMANCE; DYSFUNCTION; ACTIVATION Multiple languages Clinical Neurology; Neuroimaging; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58889