Universität zu Köln

Schumacher, Bjoern, Pothof, Joris, Vijg, Jan and Hoeijmakers, Jan H. J. (2021). The central role of DNA damage in the ageing process. Nature, 592 (7856). S. 695 - 704. BERLIN: NATURE RESEARCH. ISSN 1476-4687

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Abstract

Ageing is a complex, multifaceted process leading to widespread functional decline that affects every organ and tissue, but it remains unknown whether ageing has a unifying causal mechanism or is grounded in multiple sources. Phenotypically, the ageing process is associated with a wide variety of features at the molecular, cellular and physiological level-for example, genomic and epigenomic alterations, loss of proteostasis, declining overall cellular and subcellular function and deregulation of signalling systems. However, the relative importance, mechanistic interrelationships and hierarchical order of these features of ageing have not been clarified. Here we synthesize accumulating evidence that DNA damage affects most, if not all, aspects of the ageing phenotype, making it a potentially unifying cause of ageing. Targeting DNA damage and its mechanistic links with the ageing phenotype will provide a logical rationale for developing unified interventions to counteract age-related dysfunction and disease. This Review examines the evidence showing that DNA damage is associated with ageing phenotypes, suggesting that it may have a central role as the cause of ageing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Pothof, Joris UNSPECIFIED UNSPECIFIED UNSPECIFIED Vijg, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeijmakers, Jan H. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-589753
DOI:	10.1038/s41586-021-03307-7
Journal or Publication Title:	Nature
Volume:	592
Number:	7856
Page Range:	S. 695 - 704
Date:	2021
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	1476-4687
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58975