Universität zu Köln

Adebayo, Oyindamola Christiana ORCID: 0000-0001-5076-9983, Betukumesu, DieuMerci Kabasele, Nkoy, Agathe Bikupe, Adesoji, Oluyomi Modupe, Ekulu, Pepe Mfutu, Van den Heuvel, Lambertus P., Levtchenko, Elena N. and Labarque, Veerle (2022). Clinical and genetic factors are associated with kidney complications in African children with sickle cell anaemia. Br. J. Haematol., 196 (1). S. 204 - 215. HOBOKEN: WILEY. ISSN 1365-2141

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Abstract

Clinical and genetic factors have been reported as influencing the development of sickle cell nephropathy (SCN). However, such data remain limited in the paediatric population. In this cross-sectional study, we enrolled 361 sickle cell disease children from the Democratic Republic of Congo. Participants were genotyped for the beta (beta)-globin gene, apolipoprotein L1 (APOL1) risk variants, and haem oxygenase-1 (HMOX1) GT-dinucleotide repeats. As markers of kidney damage, albuminuria, hyperfiltration and decreased estimated glomerular filtration with creatinine (eGFRcr) were measured. An association of independent clinical and genetic factors with these markers of kidney damage were assessed via regression analysis. Genetic sequencing confirmed sickle cell anaemia in 326 participants. Albuminuria, hyperfiltration and decreased eGFRcr were present in 65 (20%), 52 (16%) and 18 (5 center dot 5%) patients, respectively. Regression analysis revealed frequent blood transfusions, indirect bilirubin and male gender as clinical predictors of SCN. APOL1 high-risk genotype (G1/G1, G2/G2 and G1/G2) was significantly associated with albuminuria (P = 0 center dot 04) and hyperfiltration (P = 0 center dot 001). HMOX1 GT-dinucleotide long repeats were significantly associated with lower eGFRcr. The study revealed a high burden of kidney damage among Congolese children and provided evidence of the possible role of APOL1 and HMOX1 in making children more susceptible to kidney complications.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Adebayo, Oyindamola Christiana UNSPECIFIED orcid.org/0000-0001-5076-9983 UNSPECIFIED Betukumesu, DieuMerci Kabasele UNSPECIFIED UNSPECIFIED UNSPECIFIED Nkoy, Agathe Bikupe UNSPECIFIED UNSPECIFIED UNSPECIFIED Adesoji, Oluyomi Modupe UNSPECIFIED UNSPECIFIED UNSPECIFIED Ekulu, Pepe Mfutu UNSPECIFIED UNSPECIFIED UNSPECIFIED Van den Heuvel, Lambertus P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Levtchenko, Elena N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Labarque, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-589913
DOI:	10.1111/bjh.17832
Journal or Publication Title:	Br. J. Haematol.
Volume:	196
Number:	1
Page Range:	S. 204 - 215
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1365-2141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RENAL-FUNCTION; GLOMERULAR HYPERFILTRATION; DISEASE; PREVALENCE; ALBUMINURIA; HEMOGLOBIN; ADULTS; MICROALBUMINURIA; PROGRESSION; APOL1 Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58991