Universität zu Köln

Otte, Kathrin A., Nolte, Viola, Mallard, Francois and Schloetterer, Christian (2021). The genetic architecture of temperature adaptation is shaped by population ancestry and not by selection regime. Genome Biol., 22 (1). LONDON: BMC. ISSN 1474-760X

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Abstract

Background Understanding the genetic architecture of temperature adaptation is key for characterizing and predicting the effect of climate change on natural populations. One particularly promising approach is Evolve and Resequence, which combines advantages of experimental evolution such as time series, replicate populations, and controlled environmental conditions, with whole genome sequencing. Recent analysis of replicate populations from two different Drosophila simulans founder populations, which were adapting to the same novel hot environment, uncovered very different architectures-either many selection targets with large heterogeneity among replicates or fewer selection targets with a consistent response among replicates. Results Here, we expose the founder population from Portugal to a cold temperature regime. Although almost no selection targets are shared between the hot and cold selection regime, the adaptive architecture was similar. We identify a moderate number of targets under strong selection (19 selection targets, mean selection coefficient = 0.072) and parallel responses in the cold evolved replicates. This similarity across different environments indicates that the adaptive architecture depends more on the ancestry of the founder population than the specific selection regime. Conclusions These observations will have broad implications for the correct interpretation of the genomic responses to a changing climate in natural populations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Otte, Kathrin A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nolte, Viola UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallard, Francois UNSPECIFIED UNSPECIFIED UNSPECIFIED Schloetterer, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-589929
DOI:	10.1186/s13059-021-02425-9
Journal or Publication Title:	Genome Biol.
Volume:	22
Number:	1
Date:	2021
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1474-760X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUANTITATIVE TRAIT LOCI; COMPLEX TRAITS; LINKAGE DISEQUILIBRIUM; STABILIZING SELECTION; POLYGENIC ADAPTATION; ARTIFICIAL SELECTION; ADAPTIVE EVOLUTION; DNA POLYMORPHISM; READ ALIGNMENT; DROSOPHILA Multiple languages Biotechnology & Applied Microbiology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58992