Universität zu Köln

Reznick, Jane, Park, Thomas J. and Lewin, Gary R. (2021). A Sweet Story of Metabolic Innovation in the Naked Mole-Rat. In: Advances in Experimental Medicine and Biology, S. 271 - 287. CHAM: SPRINGER INTERNATIONAL PUBLISHING AG. ISBN 978-3-030-65943-1; 978-3-030-65942-4

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Abstract

The naked mole-rat's (Heterocephalus glaber) social and subterranean lifestyle imposes several evolutionary pressures which have shaped its physiology. One example is low oxygen availability in a crowded burrow system which the naked mole-rat has adapted to via several mechanisms. Here we describe a metabolic rewiring which enables the naked mole-rat to switch substrates in glycolysis from glucose to fructose thereby circumventing feedback inhibition at phosphofructokinase (PFK1) to allow unrestrained glycolytic flux and ATP supply under hypoxia. Preferential shift to fructose metabolism occurs in other species and biological systems as a means to provide fuel, water or like in the naked mole-rat, protection in a low oxygen environment. We review fructose metabolism through an ecological lens and suggest that the metabolic adaptation to utilize fructose in the naked mole-rat may have evolved to simultaneously combat multiple challenges posed by its hostile environment.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Reznick, Jane UNSPECIFIED UNSPECIFIED UNSPECIFIED Park, Thomas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewin, Gary R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-590760
DOI:	10.1007/978-3-030-65943-1_10
Title of Book:	Advances in Experimental Medicine and Biology
Series Name:	Adv.Exp.Med.Biol.
Volume:	1319
Page Range:	S. 271 - 287
Date:	2021
Publisher:	SPRINGER INTERNATIONAL PUBLISHING AG
Place of Publication:	CHAM
ISSN:	2214-8019
ISBN:	978-3-030-65943-1; 978-3-030-65942-4
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOGENOUS FRUCTOSE PRODUCTION; HETEROCEPHALUS-GLABER; TRANSPORTER GLUT5; HYPOXIA TOLERANCE; INSULIN; GLUCOSE; FAT; ADAPTATION; RESPONSES; RECEPTOR Multiple languages Medicine, Research & Experimental; Zoology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59076