Universität zu Köln

Galldiks, Norbert, Werner, Jan-Michael, Lohmann, Philipp ORCID: 0000-0002-5360-046X, Kocher, Martin, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Langen, Karl-Josef (2021). Imaging of Response to Radiosurgery and Immunotherapy in Brain Metastases: Quo Vadis? Curr. Treat. Options Neurol., 23 (3). PHILADELPHIA: CURRENT MEDICINE GROUP. ISSN 1534-3138

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Abstract

Purpose of Review This review presents an overview of how advanced imaging techniques may help to overcome shortcomings of anatomical MRI for response assessment in patients with brain metastases who are undergoing stereotactic radiosurgery, immunotherapy, or combinations thereof. Recent Findings Study results suggest that parameters derived from amino acid PET, diffusion- and perfusion-weighted MRI, MR spectroscopy, and newer MRI methods are particularly helpful for the evaluation of the response to radiosurgery or checkpoint inhibitor immunotherapy and provide valuable information for the differentiation of radiotherapy-induced changes such as radiation necrosis from brain metastases. The evaluation of these imaging modalities is also of great interest in the light of emerging high-throughput analysis methods such as radiomics, which allow the acquisition of additional data at a low cost. Summary Preliminary results are promising and should be further evaluated. Shortcomings are different levels of PET and MRI standardization, the number of patients enrolled in studies, and the monocentric and retrospective character of most studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Galldiks, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Jan-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Kocher, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Langen, Karl-Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-591104
DOI:	10.1007/s11940-021-00664-6
Journal or Publication Title:	Curr. Treat. Options Neurol.
Volume:	23
Number:	3
Date:	2021
Publisher:	CURRENT MEDICINE GROUP
Place of Publication:	PHILADELPHIA
ISSN:	1534-3138
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59110