Universität zu Köln

Orlovskaya, Viktoriya V., Craig, Austin S., Fedorova, Olga S., Kuznetsova, Olga F., Neumaier, Bernd ORCID: 0000-0001-5425-3116, Krasikova, Raisa N. and Zlatopolskiy, Boris D. (2021). Production of 6-l-[F-18]Fluoro-m-tyrosine in an Automated Synthesis Module for C-11-Labeling. Molecules, 26 (18). BASEL: MDPI. ISSN 1420-3049

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Abstract

6-l-[F-18]Fluoro-m-tyrosine (6-l-[F-18]FMT) represents a valuable alternative to 6-l-[F-18]FDOPA which is conventionally used for the diagnosis and staging of Parkinson's disease. However, clinical applications of 6-l-[F-18]FMT have been limited by the paucity of practical production methods for its automated production. Herein we describe the practical preparation of 6-l-[F-18]FMT using alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral Ni(II) complex in the presence of non-basic Bu4ONTf using a volatile iPrOH/MeCN mixture as reaction solvent. A simple and fast radiolabeling procedure afforded the tracer in 20.0 +/- 3.0% activity yield within 70 min. The developed method was directly implemented onto a modified TracerLab FX C Pro platform originally designed for C-11-labeling. This method enables an uncomplicated switch between C-11- and F-18-labeling. The simplicity of the developed procedure enables its easy adaptation to other commercially available remote-controlled synthesis units and paves the way for a widespread application of 6-l-[F-18]FMT in the clinic.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Orlovskaya, Viktoriya V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Craig, Austin S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fedorova, Olga S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuznetsova, Olga F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED orcid.org/0000-0001-5425-3116 UNSPECIFIED Krasikova, Raisa N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zlatopolskiy, Boris D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-591138
DOI:	10.3390/molecules26185550
Journal or Publication Title:	Molecules
Volume:	26
Number:	18
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1420-3049
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PARKINSONS-DISEASE; AMINO-ACIDS; CURIE LEVEL; M-TYROSINE; L-DOPA; RADIOFLUORINATION; F-18-FLUORINATION; TRACERS; ANALOGS; ESTERS Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59113