Universität zu Köln

Sebeke, Lukas Christian, Rademann, Pia ORCID: 0000-0002-7136-5205, Maul, Alexandra Claudia, Yeo, Sin Yuin ORCID: 0000-0002-7602-0695, Gomez, Juan Daniel Castillo, Deenen, Daniel A., Schmidt, Patrick, de Jager, Bram, Heemels, W. P. M. H., Gruell, Holger and Heijman, Edwin (2021). Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia. Int. J. Hyperthermia, 38 (1). S. 1174 - 1188. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1464-5157

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Abstract

Purpose This article will report results from the in-vivo application of a previously published model-predictive control algorithm for MR-HIFU hyperthermia. The purpose of the investigation was to test the controller's in-vivo performance and behavior in the presence of heterogeneous perfusion. Materials and methods Hyperthermia at 42 degrees C was induced and maintained for up to 30 min in a circular section of a thermometry slice in the biceps femoris of German landrace pigs (n=5) using a commercial MR-HIFU system and a recently developed MPC algorithm. The heating power allocation was correlated with heat sink maps and contrast-enhanced MRI images. The temporal change in perfusion was estimated based on the power required to maintain hyperthermia. Results The controller performed well throughout the treatments with an absolute average tracking error of 0.27 +/- 0.15 degrees C and an average difference of 1.25 +/- 0.22 degrees C between T 10 and T 90 . The MPC algorithm allocates additional heating power to sub-volumes with elevated heat sink effects, which are colocalized with blood vessels visible on contrast-enhanced MRI. The perfusion appeared to have increased by at least a factor of similar to 1.86 on average. Conclusions The MPC controller generates temperature distributions with a narrow spectrum of voxel temperatures inside the target ROI despite the presence of spatiotemporally heterogeneous perfusion due to the rapid thermometry feedback available with MR-HIFU and the flexible allocation of heating power. The visualization of spatiotemporally heterogeneous perfusion presents new research opportunities for the investigation of stimulated perfusion in hypoxic tumor regions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sebeke, Lukas Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Rademann, Pia UNSPECIFIED orcid.org/0000-0002-7136-5205 UNSPECIFIED Maul, Alexandra Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Yeo, Sin Yuin UNSPECIFIED orcid.org/0000-0002-7602-0695 UNSPECIFIED Gomez, Juan Daniel Castillo UNSPECIFIED UNSPECIFIED UNSPECIFIED Deenen, Daniel A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED de Jager, Bram UNSPECIFIED UNSPECIFIED UNSPECIFIED Heemels, W. P. M. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruell, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Heijman, Edwin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-591238
DOI:	10.1080/02656736.2021.1933616
Journal or Publication Title:	Int. J. Hyperthermia
Volume:	38
Number:	1
Page Range:	S. 1174 - 1188
Date:	2021
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1464-5157
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTENSITY FOCUSED ULTRASOUND; TEMPORAL TEMPERATURE CONTROL; PREDICTIVE CONTROL; RANDOMIZED-TRIAL; CARDIAC-OUTPUT; BREAST-CANCER; BLOOD-FLOW; CELL-CYCLE; RADIOTHERAPY; THERMOMETRY Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59123