Sebeke, Lukas Christian, Rademann, Pia ORCID: 0000-0002-7136-5205, Maul, Alexandra Claudia, Yeo, Sin Yuin ORCID: 0000-0002-7602-0695, Gomez, Juan Daniel Castillo, Deenen, Daniel A., Schmidt, Patrick, de Jager, Bram, Heemels, W. P. M. H., Gruell, Holger and Heijman, Edwin (2021). Visualization of thermal washout due to spatiotemporally heterogenous perfusion in the application of a model-based control algorithm for MR-HIFU mediated hyperthermia. Int. J. Hyperthermia, 38 (1). S. 1174 - 1188. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1464-5157

Full text not available from this repository.

Abstract

Purpose This article will report results from the in-vivo application of a previously published model-predictive control algorithm for MR-HIFU hyperthermia. The purpose of the investigation was to test the controller's in-vivo performance and behavior in the presence of heterogeneous perfusion. Materials and methods Hyperthermia at 42 degrees C was induced and maintained for up to 30 min in a circular section of a thermometry slice in the biceps femoris of German landrace pigs (n=5) using a commercial MR-HIFU system and a recently developed MPC algorithm. The heating power allocation was correlated with heat sink maps and contrast-enhanced MRI images. The temporal change in perfusion was estimated based on the power required to maintain hyperthermia. Results The controller performed well throughout the treatments with an absolute average tracking error of 0.27 +/- 0.15 degrees C and an average difference of 1.25 +/- 0.22 degrees C between T 10 and T 90 . The MPC algorithm allocates additional heating power to sub-volumes with elevated heat sink effects, which are colocalized with blood vessels visible on contrast-enhanced MRI. The perfusion appeared to have increased by at least a factor of similar to 1.86 on average. Conclusions The MPC controller generates temperature distributions with a narrow spectrum of voxel temperatures inside the target ROI despite the presence of spatiotemporally heterogeneous perfusion due to the rapid thermometry feedback available with MR-HIFU and the flexible allocation of heating power. The visualization of spatiotemporally heterogeneous perfusion presents new research opportunities for the investigation of stimulated perfusion in hypoxic tumor regions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sebeke, Lukas ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rademann, PiaUNSPECIFIEDorcid.org/0000-0002-7136-5205UNSPECIFIED
Maul, Alexandra ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yeo, Sin YuinUNSPECIFIEDorcid.org/0000-0002-7602-0695UNSPECIFIED
Gomez, Juan Daniel CastilloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deenen, Daniel A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Jager, BramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heemels, W. P. M. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruell, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heijman, EdwinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-591238
DOI: 10.1080/02656736.2021.1933616
Journal or Publication Title: Int. J. Hyperthermia
Volume: 38
Number: 1
Page Range: S. 1174 - 1188
Date: 2021
Publisher: TAYLOR & FRANCIS LTD
Place of Publication: ABINGDON
ISSN: 1464-5157
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INTENSITY FOCUSED ULTRASOUND; TEMPORAL TEMPERATURE CONTROL; PREDICTIVE CONTROL; RANDOMIZED-TRIAL; CARDIAC-OUTPUT; BREAST-CANCER; BLOOD-FLOW; CELL-CYCLE; RADIOTHERAPY; THERMOMETRYMultiple languages
Oncology; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59123

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item