Universität zu Köln

Pechmann, Matthias, Kenny, Nathan James, Pott, Laura ORCID: 0000-0002-3314-6239, Heger, Peter ORCID: 0000-0003-2583-2981, Chen, Yen-Ta, Buchta, Thomas ORCID: 0000-0002-7040-8381, Ozuak, Orhan, Lynch, Jeremy ORCID: 0000-0001-7625-657X and Roth, Siegfried ORCID: 0000-0001-5772-3558 (2021). Striking parallels between dorsoventral patterning in Drosophila and Gryllus reveal a complex evolutionary history behind a model gene regulatory network. eLife, 10. CAMBRIDGE: eLIFE SCIENCES PUBL LTD. ISSN 2050-084X

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Abstract

Dorsoventral pattering relies on Toll and BMP signalling in all insects studied so far, with variations in the relative contributions of both pathways. Drosophila and the beetle Tribolium share extensive dependence on Toll, while representatives of more distantly related lineages like the wasp Nasonia and bug Oncopeltus rely more strongly on BMP signalling. Here, we show that in the cricket Gryllus bimaculatus, an evolutionarily distant outgroup, Toll has, like in Drosophila, a direct patterning role for the ventral half of the embryo. In addition, Toll polarises BMP signalling, although this does not involve the conserved BMP inhibitor Sog/Chordin. Finally, Toll activation relies on ovarian patterning mechanisms with striking similarity to Drosophila. Our data suggest two surprising hypotheses: (1) that Toll's patterning function in Gryllus and Drosophila is the result of convergent evolution or (2) a Drosophila-like system arose early in insect evolution and was extensively altered in multiple independent lineages.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pechmann, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Kenny, Nathan James UNSPECIFIED UNSPECIFIED UNSPECIFIED Pott, Laura UNSPECIFIED orcid.org/0000-0002-3314-6239 UNSPECIFIED Heger, Peter UNSPECIFIED orcid.org/0000-0003-2583-2981 UNSPECIFIED Chen, Yen-Ta UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchta, Thomas UNSPECIFIED orcid.org/0000-0002-7040-8381 UNSPECIFIED Ozuak, Orhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Lynch, Jeremy UNSPECIFIED orcid.org/0000-0001-7625-657X UNSPECIFIED Roth, Siegfried UNSPECIFIED orcid.org/0000-0001-5772-3558 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-591338
DOI:	10.7554/eLife.68287
Journal or Publication Title:	eLife
Volume:	10
Date:	2021
Publisher:	eLIFE SCIENCES PUBL LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DORSAL-VENTRAL POLARITY; RNA-SEQ DATA; MULTIPLE SEQUENCE ALIGNMENT; EMBRYONIC-DEVELOPMENT; TWISTED-GASTRULATION; TRIBOLIUM-CASTANEUM; AXIS FORMATION; BMP; GRADIENT; PROTEIN Multiple languages Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59133