Universität zu Köln

Wang, Shun, Zheng, Yan, Yang, Feng, Zhu, Le, Zhu, Xiao-Qiang, Wang, Zhe-Fang, Wu, Xiao-Lin, Zhou, Cheng-Hui, Yan, Jia-Yan, Hu, Bei-Yuan, Kong, Bo, Fu, De-Liang, Bruns, Christiane, Zhao, Yue, Qin, Lun-Xiu and Dong, Qiong-Zhu (2021). The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives. Signal Transduct. Target. Ther., 6 (1). LONDON: SPRINGERNATURE. ISSN 2059-3635

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Abstract

Pancreatic cancer is an increasingly common cause of cancer mortality with a tight correspondence between disease mortality and incidence. Furthermore, it is usually diagnosed at an advanced stage with a very dismal prognosis. Due to the high heterogeneity, metabolic reprogramming, and dense stromal environment associated with pancreatic cancer, patients benefit little from current conventional therapy. Recent insight into the biology and genetics of pancreatic cancer has supported its molecular classification, thus expanding clinical therapeutic options. In this review, we summarize how the biological features of pancreatic cancer and its metabolic reprogramming as well as the tumor microenvironment regulate its development and progression. We further discuss potential biomarkers for pancreatic cancer diagnosis, prediction, and surveillance based on novel liquid biopsies. We also outline recent advances in defining pancreatic cancer subtypes and subtype-specific therapeutic responses and current preclinical therapeutic models. Finally, we discuss prospects and challenges in the clinical development of pancreatic cancer therapeutics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wang, Shun UNSPECIFIED UNSPECIFIED UNSPECIFIED Zheng, Yan UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Feng UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhu, Le UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhu, Xiao-Qiang UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Zhe-Fang UNSPECIFIED UNSPECIFIED UNSPECIFIED Wu, Xiao-Lin UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhou, Cheng-Hui UNSPECIFIED UNSPECIFIED UNSPECIFIED Yan, Jia-Yan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Bei-Yuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Kong, Bo UNSPECIFIED UNSPECIFIED UNSPECIFIED Fu, De-Liang UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Yue UNSPECIFIED UNSPECIFIED UNSPECIFIED Qin, Lun-Xiu UNSPECIFIED UNSPECIFIED UNSPECIFIED Dong, Qiong-Zhu UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-591799
DOI:	10.1038/s41392-021-00659-4
Journal or Publication Title:	Signal Transduct. Target. Ther.
Volume:	6
Number:	1
Date:	2021
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	2059-3635
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CIRCULATING TUMOR DNA; NF-KAPPA-B; CANCER-ASSOCIATED FIBROBLASTS; TO-MESENCHYMAL TRANSITION; AMINO-ACID-METABOLISM; RANDOMIZED PHASE-II; DUCTAL ADENOCARCINOMA; ONCOGENIC KRAS; SIGNALING PATHWAY; CELL PLASTICITY Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59179