Lazcano-Ocampo, Claudia, van Wamelen, Daniel ORCID: 0000-0003-0921-5158, Samuel, Michael, Silverdale, Monty, Rizos, Alexandra, Sauerbier, Anna, Koch, Julia, Podlewska, Aleksandra, Leta, Valentina, Dafsari, Haidar S., Timmermann, Lars, Ashkan, Keyoumars and Chaudhuri, K. Ray . Evaluation of the effect of bilateral subthalamic nucleus deep brain stimulation on fatigue in Parkinson's Disease as measured by the non-motor symptoms scale. Br. J. Neurosurg.. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1360-046X

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Abstract

Background Fatigue is a common and disabling non-motor symptom (NMS) in Parkinson's disease (PD) patients. However, the effect of subthalamic nucleus (STN) deep brain stimulation (DBS) on fatigue has not been widely studied. Objective To determine the effect of STN DBS on fatigue in PD patients, measured by the Non-motor symptoms scale (NMSS). Methods Cross-sectional analysis of 50 patients with PD who underwent STN DBS at King's College Hospital and Salford Royal Hospital with fatigue scores (measured by question number 4 from domain 2 (sleep/fatigue) of the NMSS as the primary outcome measure. Secondary outcome measures included the PD Sleep Scale (PDSS), Scales for Outcome in PD (SCOPA)-motor examination, activities of daily living, motor complications, Hoehn and Yahr (HY) stage and changes in Levodopa Equivalent Daily Dose (LEDD). Results 50 patients with a mean follow-up period of 1.98 +/- 1.36 years were studied. Significant improvement in median fatigue scores (4.00 (0.75-9.00) to 1.00 (0.00-4.50); p = .001) was observed. In addition, improvements in question 5 (sleep maintenance and fragmentation; 8.00 (4.00-12.00) to 0.00 (0.00-4.00); p < .001) and in domain 2 total score (sleep/fatigue; 20.00 (8.75-27.25) to 6.00 (0.75-16.00); p < .001) were also significant, together with improvements in NMSS total score, SCOPA scores and HY stage (p <= .02). Moreover, LEDD but especially dopamine agonists LEDD was significantly reduced after DBS (310.00 (0.00-480.00) to 150.00 (0.00-300.00); p < .020). Conclusions Even though open label and not using a validated fatigue scale, this observational analysis suggest that fatigue improves significantly after STN DBS with persisting benefits at two years follow-up.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lazcano-Ocampo, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Wamelen, DanielUNSPECIFIEDorcid.org/0000-0003-0921-5158UNSPECIFIED
Samuel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silverdale, MontyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rizos, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sauerbier, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koch, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Podlewska, AleksandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leta, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dafsari, Haidar S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ashkan, KeyoumarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaudhuri, K. RayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-592102
DOI: 10.1080/02688697.2021.1961681
Journal or Publication Title: Br. J. Neurosurg.
Publisher: TAYLOR & FRANCIS LTD
Place of Publication: ABINGDON
ISSN: 1360-046X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEPRESSION; LEVODOPA; IMPACT; SLEEPMultiple languages
Clinical Neurology; SurgeryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59210

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