Harrison, Neale J., Connolly, Elizabeth ORCID: 0000-0002-5716-8889, Gubieda, Alicia Gascon, Yang, Zidan, Altenhein, Benjamin, Losada Perez, Maria, Moreira, Marta, Sun, Jun and Hidalgo, Alicia (2021). Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication. eLife, 10. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Understanding how injury to the central nervous system induces de novo neurogenesis in animals would help promote regeneration in humans. Regenerative neurogenesis could originate from glia and glial neuron-glia antigen-2 (NG2) may sense injury-induced neuronal signals, but these are unknown. Here, we used Drosophila to search for genes functionally related to the NG2 homologue kon-tiki (kon), and identified Islet Antigen-2 (la-2), required in neurons for insulin secretion. Both loss and over-expression of ia-2 induced neural stem cell gene expression, injury increased ia-2 expression and induced ectopic neural stem cells. Using genetic analysis and lineage tracing, we demonstrate that la-2 and Kon regulate Drosophila insulin-like peptide 6 (Dilp-6) to induce glial proliferation and neural stem cells from glia. Ectopic neural stem cells can divide, and limited de novo neurogenesis could be traced back to glial cells. Altogether, la-2 and Dilp-6 drive a neuron-glia relay that restores glia and reprogrammes glia into neural stem cells for regeneration.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Harrison, Neale J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Connolly, ElizabethUNSPECIFIEDorcid.org/0000-0002-5716-8889UNSPECIFIED
Gubieda, Alicia GasconUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yang, ZidanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altenhein, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Losada Perez, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moreira, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sun, JunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hidalgo, AliciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-592237
DOI: 10.7554/eLife.58756
Journal or Publication Title: eLife
Volume: 10
Date: 2021
Publisher: ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication: CAMBRIDGE
ISSN: 2050-084X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CENTRAL-NERVOUS-SYSTEM; VESICLE PROTEIN IA-2; NG2 GLIA; SUBCELLULAR LOCALIZATIONS; STEM-CELLS; IN-VIVO; DROSOPHILA; RECEPTOR; PROLIFERATION; PROGENITORSMultiple languages
BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59223

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