Aswendt, Markus ORCID: 0000-0003-1423-0934, Green, Claudia, Sadler, Rebecca, Llovera, Gemma, Dzikowski, Lauren ORCID: 0000-0001-8585-8089, Heindl, Steffanie, Aguero, Mercedes Gomez de, Diedenhofen, Michael, Vogel, Stefanie, Wieters, Frederique, Wiedermann, Dirk, Liesz, Arthur and Hoehn, Mathias (2021). The gut microbiota modulates brain network connectivity under physiological conditions and after acute brain ischemia. iScience, 24 (10). CAMBRIDGE: CELL PRESS. ISSN 2589-0042

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Abstract

The gut microbiome has been implicated as a key regulator of brain function in health and disease. But the impact of gut microbiota on functional brain connectivity is unknown. We used resting-state functional magnetic resonance imaging in germ-free and normally colonized mice under naive conditions and after ischemic stroke. We observed a strong, brain-wide increase of functional connectivity in germ-free animals. Graph theoretical analysis revealed significant higher values in germ-free animals, indicating a stronger and denser global network but with less structural organization. Breakdown of network function after stroke equally affected germ-free and colonized mice. Results from histological analyses showed changes in dendritic spine densities, as well as an immature microglial phenotype, indicating impaired microglia-neuron interaction in germ-free mice as potential cause of this phenomenon. These results demonstrate the substantial impact of bacterial colonization on brain-wide function and extend our so far mainly (sub) cellular understanding of the gut-brain axis.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Aswendt, MarkusUNSPECIFIEDorcid.org/0000-0003-1423-0934UNSPECIFIED
Green, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sadler, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Llovera, GemmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dzikowski, LaurenUNSPECIFIEDorcid.org/0000-0001-8585-8089UNSPECIFIED
Heindl, SteffanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aguero, Mercedes Gomez deUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diedenhofen, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vogel, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieters, FrederiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiedermann, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liesz, ArthurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoehn, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-592246
DOI: 10.1016/j.isci.2021.103095
Journal or Publication Title: iScience
Volume: 24
Number: 10
Date: 2021
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 2589-0042
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MICROGLIA; STROKE; STATE; MICE; RECOVERY; SYNAPSE; IMPACTMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59224

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