Universität zu Köln

Rumpf, Christopher, Proschinger, Sebastian, Schenk, Alexander, Bloch, Wilhelm, Lampit, Amit ORCID: 0000-0001-6522-8397, Javelle, Florian ORCID: 0000-0003-4240-2588 and Zimmer, Philipp (2021). The Effect of Acute Physical Exercise on NK-Cell Cytolytic Activity: A Systematic Review and Meta-Analysis. Sports Med., 51 (3). S. 519 - 531. NORTHCOTE: ADIS INT LTD. ISSN 1179-2035

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Abstract

Background Data on changes in natural killer cell cytolytic activity (NKCA) in response to acute physical exercise are contradictory. Objective The aim of this systematic review, meta-analysis and meta-regression is to (1) examine the effect of acute physical exercise on NKCA, (2) shed more light on the moderating factors, and (3) test the assumption of NKCA suppression subsequent to performing sports. Methods Two comparisons of NKCA were performed: (1) pre- versus post-exercise and (2) pre-exercise versus recovery. Data were acquired through a systematic search of MEDLINE (via PubMed), Scopus, and SportDiscus. Studies were eligible for inclusion if the effect of acute physical exercise was assessed including a passive control group and reporting NKCA prior to and immediately after the trial, and during the first 2 h of recovery. To better explain between-study heterogeneity, a moderator analysis was conducted. Results Pooled estimate from 12 studies reporting 18 effect sizes show that NKCA is largely elevated by acute physical exercise (Hedges' g = 1.02, 95% CI 0.59-1.46, p < 0.01). Meta-regressions reveal that this effect is larger for endurance versus resistance exercise and increases with the intensity of exercise (both p < 0.01), whereas the blood material used in the assay (p = 0.71), and the quantitative change in NK-cell count (R-2 = 0%, p = 0.55) do not play a significant role. Physical exercise does not affect the level of NKCA after the recovery period (g = 0.06, 95% CI - 0.37 to 0.50, p < 0.76). Conclusions This work provides solid evidence for elevated NKCA through performing sports which returns to baseline during the first 1-2 h of recovery, but not below the pre-exercise values providing counterevidence to the assumption of temporarily reduced NKCA. Remarkably, the functional change in NKCA exists independently from the quantitative change in NK-cell count. PROSPERO registration number: CRD42020134257.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rumpf, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Proschinger, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Lampit, Amit UNSPECIFIED orcid.org/0000-0001-6522-8397 UNSPECIFIED Javelle, Florian UNSPECIFIED orcid.org/0000-0003-4240-2588 UNSPECIFIED Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-593341
DOI:	10.1007/s40279-020-01402-9
Journal or Publication Title:	Sports Med.
Volume:	51
Number:	3
Page Range:	S. 519 - 531
Date:	2021
Publisher:	ADIS INT LTD
Place of Publication:	NORTHCOTE
ISSN:	1179-2035
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYTOTOXICITY; IMPACT; INTENSITY; INFECTION; ENDURANCE; COUNTS; NUMBER; BIAS Multiple languages Sport Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59334