Universität zu Köln

Oezkan, Filiz, Eisenmann, Stephan ORCID: 0000-0002-0387-0760, Darwiche, Kaid, Gassa, Asmae, Carbone, David P., Merritt, Robert E. and Kneuertz, Peter J. (2021). Linear Endobronchial Ultrasound in the Era of Personalized Lung Cancer Diagnostics-A Technical Review. J. Clin. Med., 10 (23). BASEL: MDPI. ISSN 2077-0383

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Abstract

Major advances in molecular profiling for available targeted treatments and immunotherapy for lung cancer have significantly increased the complexity of tissue-based diagnostics. Endobronchial ultrasound-guided transbronchial needle aspirations (EBUS-TBNA) are commonly performed for diagnostic biopsies and lymph node staging. EBUS-TBNA has increasingly become one of the main sources of tumor cells for molecular analyses. As a result, there is a growing need for high quality EBUS-TBNA samples with adequate cellularity. This has increased the technical demands of the procedure and has created additional challenges, many of which are not addressed in the current EBUS guidelines. This review provides an overview of current evidence on the technical aspects of EBUS-TBNA in light of comprehensive sample processing for personalized lung cancer management. These include sonographic lymph node characterization, optimal needle choice, suction biopsy technique, and the role of rapid on-site evaluation. Attention to these technical details will be important to maximize the throughput of EBUS-TBNA biopsies for molecular testing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Oezkan, Filiz UNSPECIFIED UNSPECIFIED UNSPECIFIED Eisenmann, Stephan UNSPECIFIED orcid.org/0000-0002-0387-0760 UNSPECIFIED Darwiche, Kaid UNSPECIFIED UNSPECIFIED UNSPECIFIED Gassa, Asmae UNSPECIFIED UNSPECIFIED UNSPECIFIED Carbone, David P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Merritt, Robert E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kneuertz, Peter J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-595937
DOI:	10.3390/jcm10235646
Journal or Publication Title:	J. Clin. Med.
Volume:	10
Number:	23
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSBRONCHIAL NEEDLE ASPIRATION; SITE CYTOLOGIC EVALUATION; EBUS-TBNA; SONOGRAPHIC FEATURES; PD-L1 EXPRESSION; LYMPH-NODES; SPECIMENS; BIOPSY; TRIAL; SUITABILITY Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59593