Universität zu Köln

Lewin, Gary R., Smith, Ewan St. J., Reznick, Jane, Debus, Karlien, Barker, Alison J. and Park, Thomas J. (2021). The Somatosensory World of the African Naked Mole-Rat. In: Advances in Experimental Medicine and Biology, S. 197 - 221. CHAM: SPRINGER INTERNATIONAL PUBLISHING AG. ISBN 978-3-030-65943-1; 978-3-030-65942-4

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Abstract

The naked mole-rat (Heterocephalus glaber) is famous for its longevity and unusual physiology. This eusocial species that lives in highly ordered and hierarchical colonies with a single breeding queen, also discovered secrets enabling somewhat pain-free living around 20 million years ago. Unlike most mammals, naked mole-rats do not feel the burn of chili pepper's active ingredient, capsaicin, nor the sting of acid. Indeed, by accumulating mutations in genes encoding proteins that are only now being exploited as targets for new pain therapies (the nerve growth factor receptor TrkA and voltage-gated sodium channel, NaV1.7), this species mastered the art of analgesia before humans evolved. Recently, we have identified pain-insensitivity as a trait shared by several closely related African mole-rat species. In this chapter we will show how African mole-rats have evolved pain insensitivity as well as discussing what the proximate factors may have been that led to the evolution of pain-free traits.

Item Type:	Book Section, Proceedings Item or annotation in a legal commentary
Creators:	Creators Email ORCID ORCID Put Code Lewin, Gary R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Smith, Ewan St. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reznick, Jane UNSPECIFIED UNSPECIFIED UNSPECIFIED Debus, Karlien UNSPECIFIED UNSPECIFIED UNSPECIFIED Barker, Alison J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Park, Thomas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-596388
DOI:	10.1007/978-3-030-65943-1_7
Title of Book:	Advances in Experimental Medicine and Biology
Series Name:	Adv.Exp.Med.Biol.
Volume:	1319
Page Range:	S. 197 - 221
Date:	2021
Publisher:	SPRINGER INTERNATIONAL PUBLISHING AG
Place of Publication:	CHAM
ISSN:	2214-8019
ISBN:	978-3-030-65943-1; 978-3-030-65942-4
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NERVE GROWTH-FACTOR; SENSING ION CHANNELS; CONGENITAL INSENSITIVITY; HETEROCEPHALUS-GLABER; CAPSAICIN RECEPTOR; MOLECULAR-BASIS; PHYSIOLOGICAL-PROPERTIES; PAIN INSENSITIVITY; CENTRAL MECHANISMS; PERIPHERAL-NERVES Multiple languages Medicine, Research & Experimental; Zoology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59638