Universität zu Köln

Jeck, Julia ORCID: 0000-0002-4669-690X, Wingen-Heimann, Sebastian M., Thielscher, Christian, Kron, Anna, Bonn, Jennifer, Jakobs, Florian, Grau, Santiago, Enoch, David A., Micallef, Christianne ORCID: 0000-0002-4513-8199, Cornely, Oliver A. and Kron, Florian (2021). Reimbursement of innovative pharmaceuticals in English and Spanish hospitals-The example of isavuconazole. Mycoses, 64 (10). S. 1213 - 1223. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Background Kron et al (Mycoses, 64, 2021, 86) found cost savings for the use of the innovative pharmaceutical isavuconazole in the inpatient setting in Germany (Bismarck-based healthcare system). Little is known about the reimbursement of innovative pharmaceuticals in the inpatient setting of Beveridge-based healthcare systems. Objectives The aim of this study was to evaluate the market access process and reimbursement of isavuconazole, exemplary for innovative pharmaceuticals, in England and Spain. Patients/Methods Market access processes of both countries were described. Focussing on typical patient clusters for isavuconazole treatment, reimbursement data regarding inpatients with (i) allogeneic haematopoietic stem cell transplantation or (ii) acute myeloid leukaemia was considered. Data were publicly available and of high topicality (England 2020/2021, Spain 2018). Discounting and a currency conversion to Euro were applied. Results This study showed that market access processes of both countries are broadly similar. Further, full reimbursement of isavuconazole as an innovative pharmaceutical may lead to reduction in resource utilisation. Without medication costs, isavuconazole can thus result in cost savings for both patient clusters due to a reduction in length of stay. Conclusions Expenses for innovative pharmaceuticals may be balanced or even lead to cost savings due to a reduction in length of stay. The latter contributes to a greater patient benefit. For both healthcare system, the analyses highlighted drugs' cost-effectiveness and assessing its added value into reimbursement decisions is highly relevant.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jeck, Julia UNSPECIFIED orcid.org/0000-0002-4669-690X UNSPECIFIED Wingen-Heimann, Sebastian M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thielscher, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kron, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonn, Jennifer UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakobs, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Grau, Santiago UNSPECIFIED UNSPECIFIED UNSPECIFIED Enoch, David A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Micallef, Christianne UNSPECIFIED orcid.org/0000-0002-4513-8199 UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kron, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-596785
DOI:	10.1111/myc.13336
Journal or Publication Title:	Mycoses
Volume:	64
Number:	10
Page Range:	S. 1213 - 1223
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INVASIVE FUNGAL-INFECTIONS; ACUTE MYELOID-LEUKEMIA; STEM-CELL TRANSPLANT; EPIDEMIOLOGY; ASPERGILLOSIS; SYSTEMS Multiple languages Dermatology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59678