Universität zu Köln

Xing, Yingying, Xu, Ning, Bhandari, Deepak D., Lapin, Dmitry, Sun, Xinhua, Luo, Xuming, Wang, Yeqiong, Cao, Jidong ORCID: 0000-0001-6794-3386, Wang, Hongbin, Coaker, Gitta, Parker, Jane E. and Liu, Jun (2021). Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization. Plant Cell, 33 (6). S. 2015 - 2032. CARY: OXFORD UNIV PRESS INC. ISSN 1532-298X

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Abstract

Acquisition of nutrients from different species is necessary for pathogen colonization. Iron is an essential mineral nutrient for nearly all organisms, but little is known about how pathogens manipulate plant hosts to acquire iron. Here, we report that AvrRps4, an effector protein delivered by Pseudomonas syringae bacteria to plants, interacts with and targets the plant iron sensor protein BRUTUS (BTS) to facilitate iron uptake and pathogen proliferation in Arabidopsis thaliana. Infection of rps4 and eds1 by P. syringae pv. tomato (Pst) DC3000 expressing AvrRps4 resulted in iron accumulation, especially in the plant apoplast. AvrRps4 alleviates BTS-mediated degradation of bHLH115 and ILR3(IAA-Leucine resistant 3), two iron regulatory proteins. In addition, BTS is important for accumulating immune proteins Enhanced Disease Susceptibility1 (EDS1) at both the transcriptional and protein levels upon Pst (avrRps4) infections. Our findings suggest that AvrRps4 targets BTS to facilitate iron accumulation and BTS contributes to RPS4/EDS1-mediated immune responses.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Xing, Yingying UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Ning UNSPECIFIED UNSPECIFIED UNSPECIFIED Bhandari, Deepak D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lapin, Dmitry UNSPECIFIED UNSPECIFIED UNSPECIFIED Sun, Xinhua UNSPECIFIED UNSPECIFIED UNSPECIFIED Luo, Xuming UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Yeqiong UNSPECIFIED UNSPECIFIED UNSPECIFIED Cao, Jidong UNSPECIFIED orcid.org/0000-0001-6794-3386 UNSPECIFIED Wang, Hongbin UNSPECIFIED UNSPECIFIED UNSPECIFIED Coaker, Gitta UNSPECIFIED UNSPECIFIED UNSPECIFIED Parker, Jane E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Jun UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-598226
DOI:	10.1093/plcell/koab075
Journal or Publication Title:	Plant Cell
Volume:	33
Number:	6
Page Range:	S. 2015 - 2032
Date:	2021
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1532-298X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IAA-LEUCINE RESISTANT3; PSEUDOMONAS-SYRINGAE; ARABIDOPSIS-THALIANA; DEFICIENCY RESPONSE; CHELATE REDUCTASE; HOMEOSTASIS; PROTEIN; SIDEROPHORE; DEFENSE; EDS1 Multiple languages Biochemistry & Molecular Biology; Plant Sciences; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59822