Universität zu Köln

Frahm, Niklas, Ellenberger, David, Fneish, Firas, Christoph, Kleinschnitz, Warnke, Clemens, Zettl, Uwe K., Friedemann, Friedemann, Rauser, Benedict, Stahmann, Alexander, Vogelmann, Vroni and Flachenecker, Peter (2021). Characteristics of secondary progressive multiple sclerosis: Disease activity and provision of care in Germany - A registry-based/multicentric cohort study. Mult. Scler. Relat. Disord., 56. OXFORD: ELSEVIER SCI LTD. ISSN 2211-0356

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Abstract

Background: The tailored immunomodulatory treatment strategy for secondary progressive multiple sclerosis (SPMS) depends on disease activity. Objective: To assess the real-world situation in monitoring disease activity in SPMS patients and to identify associations of resulting subgroups with demographics, symptomatology, and therapy Methods: This study included 4,263 SPMS patients from the German MS register (GMSR). For the classification into 'active' and 'inactive' according to relapse activity and MRI findings during the year prior to the latest clinical visit, we used the following definitions: active - gadolinium enhancing (Gd+)/new T2 lesions or >= 1 relapse, inactive - neither Gd+/new T2 lesions nor relapses. The active, inactive, and unclassifiable patients were compared in terms of clinical data, socio-demographics, symptomatology, healthcare, and DMT. Results: Classification was possible for 1,513 (35.5%) SPMS patients, with 467 classified as active and 1,046 as inactive. For the classification, MRI data was available for 33.2% of the 4,263 patients. Higher MRI frequencies were observed for younger patients (OR 1.22 [1.12,1.33] per 10 years) with short disease duration (OR 1.19 [1.09, 1.30] per 10 years) (p < 0.001). Conclusion: MRI coverage was low, especially in elderly SPMS patients. Roughly one third of the SPMS patients presented markers of disease activity in the last year. Overall, the clinical differences (concerning symptomatology and care) between patients with active and inactive SPMS were small.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Frahm, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ellenberger, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Fneish, Firas UNSPECIFIED UNSPECIFIED UNSPECIFIED Christoph, Kleinschnitz UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnke, Clemens UNSPECIFIED UNSPECIFIED UNSPECIFIED Zettl, Uwe K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Friedemann, Friedemann UNSPECIFIED UNSPECIFIED UNSPECIFIED Rauser, Benedict UNSPECIFIED UNSPECIFIED UNSPECIFIED Stahmann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogelmann, Vroni UNSPECIFIED UNSPECIFIED UNSPECIFIED Flachenecker, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-598422
DOI:	10.1016/j.msard.2021.103281
Journal or Publication Title:	Mult. Scler. Relat. Disord.
Volume:	56
Date:	2021
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2211-0356
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAGNIMS CONSENSUS GUIDELINES; MRI Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59842