Universität zu Köln

Nellessen, Nils, Onur, Oezguer A., Richter, Nils ORCID: 0000-0002-3377-5684, Jacobs, Heidi I. L., Dillen, Kim N. H., von Reutern, Boris, Langen, Karl J., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Kukolja, Juraj (2021). Differential neural structures, intrinsic functional connectivity, and episodic memory in subjective cognitive decline and healthy controls. Neurobiol. Aging, 105. S. 159 - 174. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-1497

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Abstract

The neural correlates of subjective cognitive decline (SCD; i.e., without objectifiable deficit) remain to be elucidated. Possible causes of SCD include early neurodegeneration related to Alzheimer's disease or functional and structural changes related to sub-clinical depression. We investigated the relationship between episodic memory performance or memory complaints and structural or functional magnetic resonance imaging (MRI) measures in participants with SCD ( n = 18) but without psychiatric disorders and healthy controls ( n = 31). In SCD, memory complaints were not associated with memory performance but with sub-clinical depression and executive functions. SCD-associated memory complaints correlated with higher amygdala and parahippocampal gyrus (specifically subiculum) gray matter density. In controls, but not in SCD, mesiotemporal gray matter density and superior frontal gyrus functional connectivity predicted memory performance. In contrast, in SCD, only a trend toward a correlation between memory performance and gray matter density in the parietooccipital lobes was observed. In our memory-clinic sample of SCD, we did not observe incipient neurodegeneration (limited to structural and functional MRI) but rather sub-clinical depression underlying subjective cognitive complaints. (c) 2021 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nellessen, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Oezguer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, Nils UNSPECIFIED orcid.org/0000-0002-3377-5684 UNSPECIFIED Jacobs, Heidi I. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dillen, Kim N. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Reutern, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Kukolja, Juraj UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-598518
DOI:	10.1016/j.neurobiolaging.2021.04.016
Journal or Publication Title:	Neurobiol. Aging
Volume:	105
Page Range:	S. 159 - 174
Date:	2021
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1558-1497
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDEPENDENT COMPONENT ANALYSIS; DEFAULT-MODE NETWORK; HUMAN CEREBRAL-CORTEX; RESTING-STATE FMRI; EVENT-RELATED FMRI; ALZHEIMERS-DISEASE; OLDER-ADULTS; INCREASED AMYGDALA; ENTORHINAL CORTEX; PROCESSING SPEED Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59851