Universität zu Köln

Lengefeld, Jette, Cheng, Chia-Wei, Maretich, Pema, Blair, Marguerite, Hagen, Hannah, McReynolds, Melanie R., Sullivan, Emily ORCID: 0000-0001-9558-3883, Majors, Kyra ORCID: 0000-0002-4489-7636, Roberts, Christina, Kang, Joon Ho ORCID: 0000-0003-4165-7538, Steiner, Joachim D., Miettinen, Teemu P., Manalis, Scott R., Antebi, Adam, Morrison, Sean J., Lees, Jacqueline A., Boyer, Laurie A., Yilmaz, Omer H. and Amon, Angelika (2021). Cell size is a determinant of stem cell potential during aging. Sci. Adv., 7 (46). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 2375-2548

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Abstract

Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by altered metabolism. Preventing HSC enlargement or reducing large HSCs in size averts the loss of stem cell potential under conditions causing stem cell exhaustion. Last, we show that murine and human HSCs enlarge during aging. Preventing this age-dependent enlargement improves HSC function. We conclude that small cell size is important for stem cell function in vivo and propose that stem cell enlargement contributes to their functional decline during aging.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lengefeld, Jette UNSPECIFIED UNSPECIFIED UNSPECIFIED Cheng, Chia-Wei UNSPECIFIED UNSPECIFIED UNSPECIFIED Maretich, Pema UNSPECIFIED UNSPECIFIED UNSPECIFIED Blair, Marguerite UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagen, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED McReynolds, Melanie R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sullivan, Emily UNSPECIFIED orcid.org/0000-0001-9558-3883 UNSPECIFIED Majors, Kyra UNSPECIFIED orcid.org/0000-0002-4489-7636 UNSPECIFIED Roberts, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kang, Joon Ho UNSPECIFIED orcid.org/0000-0003-4165-7538 UNSPECIFIED Steiner, Joachim D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Miettinen, Teemu P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Manalis, Scott R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Antebi, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED Morrison, Sean J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lees, Jacqueline A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boyer, Laurie A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yilmaz, Omer H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Amon, Angelika UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-599374
DOI:	10.1126/sciadv.abk0271
Journal or Publication Title:	Sci. Adv.
Volume:	7
Number:	46
Date:	2021
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	2375-2548
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEMATOPOIETIC STEM; SELF-RENEWAL; GENE-EXPRESSION; FUNCTIONAL DECLINE; PROGENITOR CELLS; GROWTH; SENESCENCE; CYCLE; HOMEOSTASIS; MTOR Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59937