Universität zu Köln

Schweitzer, Finja, Goereci, Yasemin, Franke, Christiana ORCID: 0000-0002-5609-2472, Silling, Steffi, Bosl, Fabian, Maier, Franziska ORCID: 0000-0002-9335-9594, Heger, Eva, Deiman, Birgit, Pruss, Harald, Onur, Oezguer A., Klein, Florian, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Di Cristanziano, Veronica and Warnke, Clemens (2022). Cerebrospinal Fluid Analysis Post-COVID-19 Is Not Suggestive of Persistent Central Nervous System Infection. Ann. Neurol., 91 (1). S. 150 - 158. HOBOKEN: WILEY. ISSN 1531-8249

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Abstract

This study was undertaken to assess whether SARS-CoV-2 causes a persistent central nervous system infection. SARS-CoV-2-specific antibody index and SARS-CoV-2 RNA were studied in cerebrospinal fluid following COVID-19. Cerebrospinal fluid was assessed between days 1 and 30 (n = 12), between days 31 and 90 (n = 8), or later than 90 days (post-COVID-19, n = 20) after COVID-19 diagnosis. SARS-CoV-2 RNA was absent in all patients, and in none of the 20 patients with post-COVID-19 syndrome were intrathecally produced anti-SARS-CoV-2 antibodies detected. The absence of evidence of SARS-CoV-2 in cerebrospinal fluid argues against a persistent central nervous system infection as a cause of neurological or neuropsychiatric post-COVID-19 syndrome. ANN NEUROL 2021

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schweitzer, Finja UNSPECIFIED UNSPECIFIED UNSPECIFIED Goereci, Yasemin UNSPECIFIED UNSPECIFIED UNSPECIFIED Franke, Christiana UNSPECIFIED orcid.org/0000-0002-5609-2472 UNSPECIFIED Silling, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Bosl, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Franziska UNSPECIFIED orcid.org/0000-0002-9335-9594 UNSPECIFIED Heger, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Deiman, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Pruss, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Oezguer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Di Cristanziano, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnke, Clemens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-600059
DOI:	10.1002/ana.26262
Journal or Publication Title:	Ann. Neurol.
Volume:	91
Number:	1
Page Range:	S. 150 - 158
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8249
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60005