Takeshita, Louise Y., Davidsen, Peter K., Herbert, John M., Antczak, Philipp, Hesselink, Matthijs K. C., Schrauwen, Patrick, Weisnagel, S. John, Robbins, Jeremy M., Gerszten, Robert E., Ghosh, Sujoy, Sarzynski, Mark A., Bouchard, Claude ORCID: 0000-0002-0048-491X and Falciani, Francesco (2021). Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training. Sci Rep, 11 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

Despite good adherence to supervised endurance exercise training (EET), some individuals experience no or little improvement in peripheral insulin sensitivity. The genetic and molecular mechanisms underlying this phenomenon are currently not understood. By investigating genome-wide variants associated with baseline and exercise-induced changes ( increment ) in insulin sensitivity index (S-i) in healthy volunteers, we have identified novel candidate genes whose mouse knockouts phenotypes were consistent with a causative effect on S-i. An integrative analysis of functional genomic and transcriptomic profiles suggests genetic variants have an aggregate effect on baseline S-i and increment S-i, focused around cholinergic signalling, including downstream calcium and chemokine signalling. The identification of calcium regulated MEF2A transcription factor as the most statistically significant candidate driving the transcriptional signature associated to increment S-i further strengthens the relevance of calcium signalling in EET mediated S-i response.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Takeshita, Louise Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davidsen, Peter K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herbert, John M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antczak, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hesselink, Matthijs K. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schrauwen, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weisnagel, S. JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robbins, Jeremy M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerszten, Robert E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghosh, SujoyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarzynski, Mark A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bouchard, ClaudeUNSPECIFIEDorcid.org/0000-0002-0048-491XUNSPECIFIED
Falciani, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-600666
DOI: 10.1038/s41598-021-98792-1
Journal or Publication Title: Sci Rep
Volume: 11
Number: 1
Date: 2021
Publisher: NATURE PORTFOLIO
Place of Publication: BERLIN
ISSN: 2045-2322
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PLASMA TRIGLYCERIDE RESPONSE; STIMULATED GLUCOSE-UPTAKE; INTERACTING PROTEIN 120B; MUSCLE FIBER-TYPE; SKELETAL-MUSCLE; GENE-EXPRESSION; RESISTANCE; INTERVENTION; IQCJ-SCHIP1; PREDICTORSMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60066

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