Universität zu Köln

Salokangas, R. K. R., Hietala, J., Armio, R. L., Laurikainen, H., From, T., Borgwardt, S., Riecher-Rossler, A., Brambilla, P., Bonivento, C., Meisenzahl, E., Schultze-Lutter, F., Haidl, T., Ruhrmann, S., Upthegrove, R., Wood, S. J., Pantelis, C., Kambeitz-Ilankovic, L., Ruef, A., Dwyer, D. B., Kambeitz, J. and Koutsouleris, N. (2021). Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects. Schizophr. Res., 227. S. 101 - 110. AMSTERDAM: ELSEVIER. ISSN 1573-2509

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Abstract

Background: Childhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood. Aim: To study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. Method: In seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anxiety and depression. Results: Of the CAE domains, physical abuse was associated specifically with reduced grey and white matter volumes of FroL and AmHiC in psychotic and high-risk patients. After controlling intracranial volume, PhyAb associated significantly with FroL and its grey matter volume in high-risk patients only. In mediation analyses, the effect of physical abuse on social anxiety was mediated via reduced FroL grey mater volume in high-risk patients. In them, when the effects of AmHiC and depression were controlled, the effect of physical abuse on social anxiety was mediated via FroL grey matter volume reduction. Conclusions: Childhood physical abuse is associated with reduced frontal lobe and amygdala-hippocampus complex volume in adult subjects with psychotic symptoms. Reduced frontal lobe and amygdala-hippocampus complex volume mediate the effect of physical abuse on social anxiety in high-risk patients. The effect of physical abuse on depression-independent social anxiety is mediated via reduced frontal lobe. (C) 2020 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Salokangas, R. K. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hietala, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Armio, R. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Laurikainen, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED From, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgwardt, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riecher-Rossler, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brambilla, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonivento, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meisenzahl, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultze-Lutter, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haidl, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Upthegrove, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wood, S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pantelis, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz-Ilankovic, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruef, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dwyer, D. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kambeitz, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koutsouleris, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601338
DOI:	10.1016/j.schres.2020.05.041
Journal or Publication Title:	Schizophr. Res.
Volume:	227
Page Range:	S. 101 - 110
Date:	2021
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1573-2509
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60133