Universität zu Köln

Hecht, Markus ORCID: 0000-0003-2082-216X, Hahn, Dennis, Wolber, Philipp, Hautmann, Matthias G., Reichert, Dietmar, Weniger, Steffi, Belk, Claus, Bergmann, Tobias, Goehler, Thomas, Welslau, Manfred, Gross-Thie, Christina, Guntinas-Lichius, Orlando ORCID: 0000-0001-9671-0784, von der Gruen, Jens ORCID: 0000-0002-9371-7814, Balermpas, Panagiotis ORCID: 0000-0001-5261-6446, Orlowski, Katrin, Messinger, Diethelm, Stenzel, Karsten G. and Fietkau, Rainer (2021). A Prospective Real-World Multi-Center Study to Evaluate Progression-Free and Overall Survival of Radiotherapy with Cetuximab and Platinum-Based Chemotherapy with Cetuximab in Locally Recurrent Head and Neck Cancer. Cancers, 13 (14). BASEL: MDPI. ISSN 2072-6694

Full text not available from this repository.

Abstract

Simple Summary Despite recent developments in immune checkpoint inhibitors, the treatment of locoregionally recurrent head and neck squamous cell cancer (HNSCC) remains challenging. Prospective data comparing re-irradiation with systemic treatment are not available. The SOCCER trial represents a prospective non-interventional multicenter trial that enrolled patients with locoregionally recurrent HNSCC treated with cetuximab in combination with re-radiotherapy or chemotherapy. A total of 192 patients were analyzed. Radiotherapy combined with cetuximab had superior progression-free and overall survival compared to chemotherapy with cetuximab. This highlights the high efficacy of local re-radiotherapy in combination with cetuximab in patients with locoregionally recurrent HNSCC. Treatment options of locoregional recurrent head and neck squamous cell cancer (HNSCC) include both local strategies as surgery or re-radiotherapy and systemic therapy. In this prospective, multi-center, non-interventional study, patients were treated either with platinum-based chemotherapy and cetuximab (CT + Cet) or re-radiotherapy and cetuximab (RT + Cet). In the current analysis, progression-free survival (PFS) and overall survival (OS) were compared in patients with locoregional recurrence. Four hundred seventy patients were registered in 97 German centers. After exclusion of patients with distant metastases, a cohort of 192 patients was analyzed (129 CT + Cet, 63 RT + Cet). Radiotherapy was delivered as re-irradiation to 70% of the patients. The mean radiation dose was 51.8 Gy, whereas a radiation dose of >= 60 Gy was delivered in 33% of the patients. Chemotherapy mainly consisted of cisplatin/5-flurouracil (40%) or carboplatin/5-flurouracil (29%). The median PFS was 9.2 months in the RT + Cet group versus 5.1 months in the CT + Cet group (hazard ratio for disease progression or death, 0.40, 95% CI, 0.27-0.57, p < 0.0001). Median OS was 12.8 months in the RT + Cet group versus 7.9 months in the CT + Cet group (hazard ratio for death, 0.50, 95% CI, 0.33-0.75, p = 0.0008). In conclusion, radiotherapy combined with cetuximab improved survival compared to chemotherapy combined with cetuximab in locally recurrent HNSCC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hecht, Markus UNSPECIFIED orcid.org/0000-0003-2082-216X UNSPECIFIED Hahn, Dennis UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolber, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Hautmann, Matthias G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reichert, Dietmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Weniger, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Belk, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergmann, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Goehler, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Welslau, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Gross-Thie, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Guntinas-Lichius, Orlando UNSPECIFIED orcid.org/0000-0001-9671-0784 UNSPECIFIED von der Gruen, Jens UNSPECIFIED orcid.org/0000-0002-9371-7814 UNSPECIFIED Balermpas, Panagiotis UNSPECIFIED orcid.org/0000-0001-5261-6446 UNSPECIFIED Orlowski, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Messinger, Diethelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Stenzel, Karsten G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fietkau, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-601789
DOI:	10.3390/cancers13143413
Journal or Publication Title:	Cancers
Volume:	13
Number:	14
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; REIRRADIATION; PEMBROLIZUMAB; RISK Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60178