Universität zu Köln

Duhan, Vikas ORCID: 0000-0002-6337-8225, Khairnar, Vishal ORCID: 0000-0002-3584-7530, Kitanovski, Simo, Hamdan, Thamer A., Klein, Andres D., Lang, Judith, Ali, Murtaza, Adomati, Tom, Bhat, Hilal, Friedrich, Sarah-Kim, Li, Fanghui, Krebs, Philippe ORCID: 0000-0003-4918-6654, Futerman, Anthony H., Addo, Marylyn M., Hardt, Cornelia, Hoffmann, Daniel ORCID: 0000-0003-2973-7869, Lang, Philipp A. and Lang, Karl S. (2021). Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells. Front. Immunol., 11. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-3224

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Abstract

Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we identified Integrin alpha-E (Itgae, CD103) as a new regulator of antiviral IFN-I production in a mouse model of vesicular stomatitis virus (VSV) infection. CD103 was specifically expressed by splenic conventional dendritic cells (cDCs) and limited IFN-I production in these cells during VSV infection. Mechanistically, CD103 suppressed AKT phosphorylation and mTOR activation in DCs. Deficiency in CD103 accelerated early IFN-I in cDCs and prevented death in VSV infected animals. In conclusion, CD103 participates in regulation of cDC specific IFN-I induction and thereby influences immune activation after VSV infection.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Duhan, Vikas UNSPECIFIED orcid.org/0000-0002-6337-8225 UNSPECIFIED Khairnar, Vishal UNSPECIFIED orcid.org/0000-0002-3584-7530 UNSPECIFIED Kitanovski, Simo UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamdan, Thamer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Andres D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Ali, Murtaza UNSPECIFIED UNSPECIFIED UNSPECIFIED Adomati, Tom UNSPECIFIED UNSPECIFIED UNSPECIFIED Bhat, Hilal UNSPECIFIED UNSPECIFIED UNSPECIFIED Friedrich, Sarah-Kim UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Fanghui UNSPECIFIED UNSPECIFIED UNSPECIFIED Krebs, Philippe UNSPECIFIED orcid.org/0000-0003-4918-6654 UNSPECIFIED Futerman, Anthony H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Addo, Marylyn M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hardt, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Daniel UNSPECIFIED orcid.org/0000-0003-2973-7869 UNSPECIFIED Lang, Philipp A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Karl S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-602360
DOI:	10.3389/fimmu.2020.607889
Journal or Publication Title:	Front. Immunol.
Volume:	11
Date:	2021
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-3224
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60236