Universität zu Köln

Orel, Rok, Benninga, Marc A., Broekaert, Ilse J., Gottrand, Frederic, Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Thomson, Mike, Wilschanski, Michael and Thapar, Nikhil (2021). Drugs in Focus: Proton Pump Inhibitors. J. Pediatr. Gastroenterol. Nutr., 72 (5). S. 645 - 654. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-4801

Full text not available from this repository.

Abstract

Proton pump inhibitors (PPIs) are amongst the most commonly prescribed drugs in infants and children with the last decades witnessing a dramatic rise in their utilization. Although PPIs are clearly effective when used appropriately and have been regarded as safe drugs, there is growing evidence regarding their potential adverse effects. Although, largely based on adult data it is clear that many of these are also relevant to pediatrics. PPI use potentially affects gastrointestinal microbiota composition and function, decreases defence against pathogens resulting in increased risk for infections, interferes with absorption of minerals and vitamins leading to specific deficiencies and increased risk for bone fractures as well as interferes with protein digestion resulting in increased risk of sensitization to allergens and development of allergic diseases and eosinophilic esophagitis. An association with gastric, liver and pancreatic cancer has also been inferred from adult data but is tenuous and causation is not proven. Overall, evidence for these adverse events is patchy and not always compelling. Overall, the use of PPIs, for selected indications with a good evidence base, has significant potential benefit but carries more caution in infants and children. Pediatricians should be aware of the concerns regarding the potential adverse events associated with their use.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Orel, Rok UNSPECIFIED UNSPECIFIED UNSPECIFIED Benninga, Marc A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Broekaert, Ilse J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottrand, Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Papadopoulou, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Ribes-Koninckx, Carmen UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomson, Mike UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilschanski, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Thapar, Nikhil UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-602508
DOI:	10.1097/MPG.0000000000003063
Journal or Publication Title:	J. Pediatr. Gastroenterol. Nutr.
Volume:	72
Number:	5
Page Range:	S. 645 - 654
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-4801
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GASTROESOPHAGEAL-REFLUX DISEASE; LONG-TERM USE; CLOSTRIDIUM-DIFFICILE INFECTION; HELICOBACTER-PYLORI INFECTION; RECEPTOR ANTAGONIST USE; EOSINOPHILIC ESOPHAGITIS; PEDIATRIC-PATIENTS; HEPATIC-ENCEPHALOPATHY; BACTERIAL OVERGROWTH; ACID SUPPRESSION Multiple languages Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60250