Universität zu Köln

Feldkotter, Markus, Thys, Sarah, Adams, Anne ORCID: 0000-0003-3286-1131, Becker, Ingrid ORCID: 0000-0001-5829-3553, Buescher, Rainer, Pohl, Martin, Schild, Raphael, Pape, Lars, Schmitt, Claus Peter, Taylan, Christina, Wygoda, Simone, Klaus, Guenter, Fehrenbach, Henry, Montoya, Carmen, Konrad, Martin, Billing, Heiko, Schaar, Bettina and Hoppe, Bernd (2020). Endurance-oriented training program with children and adolescents on maintenance hemodialysis to enhance dialysis efficacy-DiaSport. Pediatr. Nephrol., 36 (12). S. 3923 - 3933. NEW YORK: SPRINGER. ISSN 1432-198X

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Abstract

Objective Pediatric patients spend significant time on maintenance hemodialysis (HD) and traveling. They are often not capable of participating in sports activities. To assess the effects of exercise training during HD on dialysis efficacy in children and adolescents, we set up a multi-center randomized controlled trial (RCT). Methods Patients on HD, age 6 to 18 years, were randomized either to 3x weekly bicycle ergometer training or to no train g during HD for 12 weeks. Change in single-pool KtN (spKt/V) was the primary outcome parameter. Results We randomized 54 patients of whom 45 qualified (23 in the intervention and 22 in the waiting control group, 14.5 +/- 3.01 years, 32 male and 13 female) for the intention-to-treat (ITT) population. Only 26 patients fmished study per-protocol (PP). Training was performed for an average of 11.96 weeks (0.14-13.14) at 2.08 +/- 0.76 times per week and for a weekly mean of 55.52 +/- 27.26 min. Single-pool Kt/V was similar in the intervention compared to the control group (1.70 [0.33] vs. 1.79 [0.55]) at VO and (1.70 [0.36] vs. 1.71 [0.51]) at V1; secondary endpoints also showed no difference in both ITT and PP analysis. No significant adverse events were reported. No bleeding or needle dislocation occurred in 1670 training sessions. Conclusions Intradialytic bicycle training is safe, but does not improve dialysis efficacy and physical fitness. However, the study can be considered underpowered, particularly because of high dropout rates. Future studies need better strategies to increase motivation and compliance and other more effective/intensive exercise measures should be evaluated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Feldkotter, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Thys, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Adams, Anne UNSPECIFIED orcid.org/0000-0003-3286-1131 UNSPECIFIED Becker, Ingrid UNSPECIFIED orcid.org/0000-0001-5829-3553 UNSPECIFIED Buescher, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Pohl, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schild, Raphael UNSPECIFIED UNSPECIFIED UNSPECIFIED Pape, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitt, Claus Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Taylan, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Wygoda, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Klaus, Guenter UNSPECIFIED UNSPECIFIED UNSPECIFIED Fehrenbach, Henry UNSPECIFIED UNSPECIFIED UNSPECIFIED Montoya, Carmen UNSPECIFIED UNSPECIFIED UNSPECIFIED Konrad, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Billing, Heiko UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaar, Bettina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-602974
DOI:	10.1007/s00467-021-05114-8
Journal or Publication Title:	Pediatr. Nephrol.
Volume:	36
Number:	12
Page Range:	S. 3923 - 3933
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-198X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STAGE RENAL-DISEASE; INTRADIALYTIC EXERCISE; PERFORMANCE Multiple languages Pediatrics; Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60297