Universität zu Köln

Zellmer, Stephan, Hanses, Frank ORCID: 0000-0002-0007-8014, Muzalyova, Anna, Classen, Johanna, Braun, Georg, Piepel, Christiane, Erber, Johanna, Pilgram, Lisa, Walter, Lorenz, Goepel, Siri, Wille, Kai ORCID: 0000-0002-7682-8563, Hower, Martin, Ruethrich, Maria Madeleine, Rupp, Jan ORCID: 0000-0001-8722-1233, Degenhardt, Christian, Voigt, Ingo, Borgmann, Stefan, Stecher, Melanie, Jakob, Carolin, Dhillon, Christine, Messmann, Helmut, Ebigbo, Alanna and Roemmele, Christoph (2021). Gastrointestinal bleeding and endoscopic findings in critically and non-critically ill patients with corona virus disease 2019 (COVID-19): Results from Lean European Open Survey on SARS-CoV-2 (LEOSS) and COKA registries. United European Gastroenterol. J., 9 (9). S. 1081 - 1091. CHICHESTER: JOHN WILEY & SONS LTD. ISSN 2050-6414

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Abstract

Background Corona virus disease 2019 (COVID-19) patients are at increased risk for thromboembolic events. It is unclear whether the risk for gastrointestinal (GI) bleeding is also increased. Methods We considered 4128 COVID-19 patients enrolled in the Lean European Open Survey on SARS-CoV-2 (LEOSS) registry. The association between occurrence of GI bleeding and comorbidities as well as medication were examined. In addition, 1216 patients from COKA registry were analyzed focusing on endoscopy diagnostic findings. Results A cumulative number of 97 patients (1.8%) with GI bleeding were identified in the LEOSS registry and COKA registry. Of 4128 patients from the LEOSS registry, 66 patients (1.6%) had a GI bleeding. The rate of GI bleeding in patients with intensive care unit (ICU) admission was 4.5%. The use of therapeutic dose of anticoagulants showed a significant association with the increased incidence of bleeding in the critical phase of disease. The Charlson comorbidity index and the COVID-19 severity index were significantly higher in the group of patients with GI bleeding than in the group of patients without GI bleeding (5.83 (SD = 2.93) vs. 3.66 (SD = 3.06), p < 0.01 and 3.26 (SD = 1.69) vs. 2.33 (SD = 1.53), p < 0.01, respectively). In the COKA registry 31 patients (2.5%) developed a GI bleeding. Of these, the source of bleeding was identified in upper GI tract in 21 patients (67.7%) with ulcer as the most frequent bleeding source (25.8%, n = 8) followed by gastroesophageal reflux (16.1%, n = 5). In three patients (9.7%) GI bleeding source was located in lower GI tract caused mainly by diverticular bleeding (6.5%, n = 2). In seven patients (22.6%) the bleeding localization remained unknown. Conclusion Consistent with previous research, comorbidities and disease severity correlate with the incidence of GI bleeding. Also, therapeutic anticoagulation seems to be associated with a higher risk of GI bleeding. Overall, the risk of GI bleeding seems not to be increased in COVID-19 patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zellmer, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hanses, Frank UNSPECIFIED orcid.org/0000-0002-0007-8014 UNSPECIFIED Muzalyova, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Classen, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Braun, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Piepel, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Erber, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilgram, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, Lorenz UNSPECIFIED UNSPECIFIED UNSPECIFIED Goepel, Siri UNSPECIFIED UNSPECIFIED UNSPECIFIED Wille, Kai UNSPECIFIED orcid.org/0000-0002-7682-8563 UNSPECIFIED Hower, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruethrich, Maria Madeleine UNSPECIFIED UNSPECIFIED UNSPECIFIED Rupp, Jan UNSPECIFIED orcid.org/0000-0001-8722-1233 UNSPECIFIED Degenhardt, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Voigt, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Borgmann, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Stecher, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakob, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Dhillon, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Messmann, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebigbo, Alanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Roemmele, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-603078
DOI:	10.1002/ueg2.12165
Journal or Publication Title:	United European Gastroenterol. J.
Volume:	9
Number:	9
Page Range:	S. 1081 - 1091
Date:	2021
Publisher:	JOHN WILEY & SONS LTD
Place of Publication:	CHICHESTER
ISSN:	2050-6414
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROPHYLAXIS; MANAGEMENT; SOCIETY Multiple languages Gastroenterology & Hepatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60307