Dietzsch, Stefan, Braesigk, Annett, Seidel, Clemens, Remmele, Julia, Kitzing, Ralf, Schlender, Tina, Mynarek, Martin, Geismar, Dirk, Jablonska, Karolina, Schwarz, Rudolf, Pazos, Montserrat, Weber, Damien C., Frick, Silke, Gurtner, Kristin, Matuschek, Christiane, Harrabi, Semi Ben, Gluck, Albrecht, Lewitzki, Victor ORCID: 0000-0001-9146-3083, Dieckmann, Karin, Benesch, Martin, Gerber, Nicolas U., Obrecht, Denise, Rutkowski, Stefan, Timmermann, Beate and Kortmann, Rolf-Dieter (2022). Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma-an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial. Strahlenther. Onkol., 198 (3). S. 282 - 291. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-099X

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Abstract

Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Dietzsch, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braesigk, AnnettUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidel, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Remmele, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kitzing, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlender, TinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mynarek, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geismar, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jablonska, KarolinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwarz, RudolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pazos, MontserratUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, Damien C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frick, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gurtner, KristinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matuschek, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harrabi, Semi BenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gluck, AlbrechtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lewitzki, VictorUNSPECIFIEDorcid.org/0000-0001-9146-3083UNSPECIFIED
Dieckmann, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benesch, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerber, Nicolas U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obrecht, DeniseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rutkowski, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Timmermann, BeateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kortmann, Rolf-DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-603173
DOI: 10.1007/s00066-021-01822-0
Journal or Publication Title: Strahlenther. Onkol.
Volume: 198
Number: 3
Page Range: S. 282 - 291
Date: 2022
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1439-099X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CRANIOSPINAL IRRADIATION; PEDIATRIC MEDULLOBLASTOMA; RISK MEDULLOBLASTOMA; IMAGE REGISTRATION; CHEMOTHERAPY; ASSURANCE; IMPACT; VARIABILITY; DELINEATION; SOCIETYMultiple languages
Oncology; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60317

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