Upthegrove, Rachel ORCID: 0000-0001-8204-5103, Lalousis, Paris, Mallikarjun, Pavan ORCID: 0000-0002-9902-9254, Chisholm, Katharine ORCID: 0000-0002-0575-0789, Griffiths, Sian Lowri, Iqbal, Mariam, Pelton, Mirabel, Reniers, Renate ORCID: 0000-0003-4119-2486, Stainton, Alexandra ORCID: 0000-0002-4969-3122, Rosen, Marlene, Ruef, Anne, Dwyer, Dominic B., Surman, Marian, Haidl, Theresa, Penzel, Nora, Kambeitz-Llankovic, Lana, Bertolino, Alessandro, Brambilla, Paolo, Borgwardt, Stefan, Kambeitz, Joseph, Lencer, Rebekka, Pantelis, Christos, Ruhrmann, Stephan, Schultze-Lutter, Frauke, Salokangas, Raimo K. R., Meisenzahl, Eva, Wood, Stephen J. and Koutsouleris, Nikolaos (2021). The Psychopathology and Neuroanatomical Markers of Depression in Early Psychosis. Schizophr. Bull., 47 (1). S. 249 - 259. OXFORD: OXFORD UNIV PRESS. ISSN 1745-1701

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Abstract

Depression frequently occurs in first-episode psychosis (FEP) and predicts longer-term negative outcomes. It is possible that this depression is seen primarily in a distinct subgroup, which if identified could allow targeted treatments. We hypothesize that patients with recent-onset psychosis (ROP) and comorbid depression would be identifiable by symptoms and neuroanatomical features similar to those seen in recent-onset depression (ROD). Data were extracted from the multisite PRONIA study: 154 ROP patients (FEP within 3 months of treatment onset), of whom 83 were depressed (ROP+D) and 71 who were not depressed (ROP-D), 146 ROD patients, and 265 healthy controls (HC). Analyses included a (1) principal component analysis that established the similar symptom structure of depression in ROD and ROP+D, (2) supervised machine learning (ML) classification with repeated nested cross-validation based on depressive symptoms separating ROD vs ROP+D, which achieved a balanced accuracy (BAC) of 51%, and (3) neuroanatomical ML-based classification, using regions of interest generated from ROD subjects, which identified BAC of 50% (no better than chance) for separation of ROP+D vs ROP-D. We conclude that depression at a symptom level is broadly similar with or without psychosis status in recent-onset disorders; however, this is not driven by a separable depressed subgroup in FEP. Depression may be intrinsic to early stages of psychotic disorder, and thus treating depression could produce widespread benefit.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Upthegrove, RachelUNSPECIFIEDorcid.org/0000-0001-8204-5103UNSPECIFIED
Lalousis, ParisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mallikarjun, PavanUNSPECIFIEDorcid.org/0000-0002-9902-9254UNSPECIFIED
Chisholm, KatharineUNSPECIFIEDorcid.org/0000-0002-0575-0789UNSPECIFIED
Griffiths, Sian LowriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iqbal, MariamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pelton, MirabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reniers, RenateUNSPECIFIEDorcid.org/0000-0003-4119-2486UNSPECIFIED
Stainton, AlexandraUNSPECIFIEDorcid.org/0000-0002-4969-3122UNSPECIFIED
Rosen, MarleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruef, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dwyer, Dominic B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Surman, MarianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haidl, TheresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Penzel, NoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz-Llankovic, LanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertolino, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brambilla, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lencer, RebekkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantelis, ChristosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultze-Lutter, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salokangas, Raimo K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meisenzahl, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wood, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koutsouleris, NikolaosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-603190
DOI: 10.1093/schbul/sbaa094
Journal or Publication Title: Schizophr. Bull.
Volume: 47
Number: 1
Page Range: S. 249 - 259
Date: 2021
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1745-1701
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
1ST EPISODE PSYCHOSIS; SCHIZOPHRENIA; METAANALYSIS; RISK; ANTIDEPRESSANTS; ANTIPSYCHOTICS; INDIVIDUALS; DISORDERS; SYMPTOMS; ONSETMultiple languages
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60319

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