Universität zu Köln

Ong, Hui Lin, Isvoranu, Adela-Maria, Schirmbeck, Frederike ORCID: 0000-0003-1700-0958, McGuire, Philip ORCID: 0000-0003-4381-0532, Valmaggia, Lucia ORCID: 0000-0001-6099-8464, Kempton, Matthew J., van der Gaag, Mark ORCID: 0000-0002-3525-6415, Riecher-Rossler, Anita, Bressan, Rodrigo A., Barrantes-Vidal, Neus ORCID: 0000-0002-8671-1238, Nelson, Barnaby ORCID: 0000-0002-6263-2332, Amminger, G. Paul, McGorry, Patrick ORCID: 0000-0002-3789-6168, Pantelis, Christos ORCID: 0000-0002-9565-0238, Krebs, Marie-Odile ORCID: 0000-0002-4715-9890, Nordentoft, Merete, Glenthoj, Birte, Ruhrmann, Stephan, Sachs, Gabriele ORCID: 0000-0002-8359-9877, Rutten, Bart P. F., van Os, Jim, de Haan, Lieuwe and Borsboom, Denny (2021). Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective. Schizophr. Bull., 47 (4). S. 1018 - 1029. OXFORD: OXFORD UNIV PRESS. ISSN 1745-1701

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Abstract

Background: The high prevalence of obsessive-compulsive symptoms (OCS) among subjects at Ultra-High Risk (UHR) for psychosis is well documented. However, the network structure spanning the relations between OCS and symptoms of the at risk mental state for psychosis as assessed with the Comprehensive Assessment of At Risk Mental States (CAARMS) has not yet been investigated. This article aimed to use a network approach to investigate the associations between OCS and CAARMS symptoms in a large sample of individuals with different levels of risk for psychosis. Method: Three hundred and forty-one UHR and 66 healthy participants were included, who participated in the EU-GE1 study. Data analysis consisted of constructing a network of CAARMS symptoms, investigating central items in the network, and identifying the shortest pathways between OCS and positive symptoms. Results: Strong associations between OCS and anxiety, social isolation and blunted affect were identified. Depression was the most central symptom in terms of the number of connections, and anxiety was a key item in bridging OCS to other symptoms. Shortest paths between OCS and positive symptoms revealed that unusual thought content and perceptual abnormalities were connected mainly via anxiety, while disorganized speech was connected via blunted affect and cognitive change. Conclusions: Findings provide valuable insight into the central role of depression and the potential connective component of anxiety between OCS and other symptoms of the network. Interventions specifically aimed to reduce affective symptoms might be crucial for the development and prospective course of symptom co-occurrence.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ong, Hui Lin UNSPECIFIED UNSPECIFIED UNSPECIFIED Isvoranu, Adela-Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Schirmbeck, Frederike UNSPECIFIED orcid.org/0000-0003-1700-0958 UNSPECIFIED McGuire, Philip UNSPECIFIED orcid.org/0000-0003-4381-0532 UNSPECIFIED Valmaggia, Lucia UNSPECIFIED orcid.org/0000-0001-6099-8464 UNSPECIFIED Kempton, Matthew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Gaag, Mark UNSPECIFIED orcid.org/0000-0002-3525-6415 UNSPECIFIED Riecher-Rossler, Anita UNSPECIFIED UNSPECIFIED UNSPECIFIED Bressan, Rodrigo A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barrantes-Vidal, Neus UNSPECIFIED orcid.org/0000-0002-8671-1238 UNSPECIFIED Nelson, Barnaby UNSPECIFIED orcid.org/0000-0002-6263-2332 UNSPECIFIED Amminger, G. Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED McGorry, Patrick UNSPECIFIED orcid.org/0000-0002-3789-6168 UNSPECIFIED Pantelis, Christos UNSPECIFIED orcid.org/0000-0002-9565-0238 UNSPECIFIED Krebs, Marie-Odile UNSPECIFIED orcid.org/0000-0002-4715-9890 UNSPECIFIED Nordentoft, Merete UNSPECIFIED UNSPECIFIED UNSPECIFIED Glenthoj, Birte UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Sachs, Gabriele UNSPECIFIED orcid.org/0000-0002-8359-9877 UNSPECIFIED Rutten, Bart P. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Os, Jim UNSPECIFIED UNSPECIFIED UNSPECIFIED de Haan, Lieuwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Borsboom, Denny UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-604122
DOI:	10.1093/schbul/sbaa187
Journal or Publication Title:	Schizophr. Bull.
Volume:	47
Number:	4
Page Range:	S. 1018 - 1029
Date:	2021
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1745-1701
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRA-HIGH RISK; COMPREHENSIVE ASSESSMENT; CHILDHOOD TRAUMA; DISORDER; SCHIZOPHRENIA; VULNERABILITY; ASSOCIATIONS; METAANALYSIS; INDIVIDUALS; SPECTRUM Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60412