Ballarini, Tommaso ORCID: 0000-0001-7299-5973, van Lent, Debora Melo, Brunner, Julia, Schroeder, Alina, Wolfsgruber, Steffen, Altenstein, Slawek, Brosseron, Frederic ORCID: 0000-0003-3137-7516, Buerger, Katharina, Dechent, Peter, Dobisch, Laura, Duezel, Emrah, Ertl-Wagner, Birgit, Fliessbach, Klaus, Freiesleben, Silka Dawn, Frommann, Ingo, Glanz, Wenzel, Hauser, Dietmar, Haynes, John Dylan, Heneka, Michael T., Janowitz, Daniel, Kilimann, Ingo, Laske, Christoph, Maier, Franziska ORCID: 0000-0002-9335-9594, Metzger, Coraline Danielle, Munk, Matthias, Perneczky, Robert, Peters, Oliver, Priller, Josef ORCID: 0000-0001-7596-0979, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Rauchmann, Boris, Roy, Nina, Scheffler, Klaus, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Teipel, Stefan J., Vukovich, Ruth, Wiltfang, Jens, Jessen, Frank and Wagner, Michael ORCID: 0000-0003-2589-6440 (2021). Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age. Neurology, 96 (24). S. E2920 - 13. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1526-632X

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Abstract

Objective To determine whether following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer disease (AD), we analyzed cross-sectional data from the German DZNE-Longitudinal Cognitive Impairment and Dementia Study. Method The sample (n = 512, mean age 69.5 +/- 5.9 years) included 169 cognitively normal participants and individuals at higher AD risk (53 with relatives with AD, 209 with subjective cognitive decline, and 81 with mild cognitive impairment). We defined MeDi adherence according to the food frequency questionnaire. Brain volume outcomes were generated via voxel-based morphometry on T1-MRI, and cognitive performance was assessed with an extensive neuropsychological battery. AD-related biomarkers (beta-amyloid(42/40) [A beta(42/40)] ratio, phosphorylated tau 181 [pTau181]) in CSF were assessed in n = 226 individuals. We analyzed the associations between MeDi and outcomes with linear regression models controlling for several covariates. In addition, we applied hypothesis-driven mediation and moderation analysis. Results Higher MeDi adherence related to larger mediotemporal gray matter volume (p < 0.05 family-wise error corrected), better memory (beta +/- SE = 0.03 +/- 0.02; p = 0.038), and less amyloid (A beta(42/40) ratio, beta +/- SE = 0.003 +/- 0.001; p = 0.008) and pTau181 (beta +/- SE = -1.96 +/- 0.68; p = 0.004) pathology. Mediotemporal volume mediated the association between MeDi and memory (40% indirect mediation). Finally, MeDi favorably moderated the associations among A beta(42/40) ratio, pTau181, and mediotemporal atrophy. Results were consistent correcting for APOE-epsilon 4 status. Conclusion Our findings corroborate the view of MeDi as a protective factor against memory decline and mediotemporal atrophy. They suggest that these associations might be explained by a decrease of amyloidosis and tau pathology. Longitudinal and dietary intervention studies should further examine this conjecture and its treatment implications.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ballarini, TommasoUNSPECIFIEDorcid.org/0000-0001-7299-5973UNSPECIFIED
van Lent, Debora MeloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunner, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroeder, AlinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altenstein, SlawekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brosseron, FredericUNSPECIFIEDorcid.org/0000-0003-3137-7516UNSPECIFIED
Buerger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dechent, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dobisch, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duezel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ertl-Wagner, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Freiesleben, Silka DawnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frommann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glanz, WenzelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hauser, DietmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haynes, John DylanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heneka, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janowitz, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilimann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laske, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, FranziskaUNSPECIFIEDorcid.org/0000-0002-9335-9594UNSPECIFIED
Metzger, Coraline DanielleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munk, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perneczky, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priller, JosefUNSPECIFIEDorcid.org/0000-0001-7596-0979UNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Rauchmann, BorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roy, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheffler, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spruth, Eike JakobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teipel, Stefan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vukovich, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltfang, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
URN: urn:nbn:de:hbz:38-604213
DOI: 10.1212/WNL.0000000000012067
Journal or Publication Title: Neurology
Volume: 96
Number: 24
Page Range: S. E2920 - 13
Date: 2021
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1526-632X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUBJECTIVE COGNITIVE DECLINE; PHYSICAL-ACTIVITY; AMYLOID-BETA; IMPAIRMENT; DEMENTIA; RISK; TAU; ASSOCIATION; ADHERENCE; ADULTSMultiple languages
Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60421

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