Mauvais-Jarvis, Franck ORCID: 0000-0002-0874-0754, Berthold, Heiner K., Campesi, Ilaria, Carrero, Juan-Jesus, Dakal, Santosh, Franconi, Flavia, Gouni-Berthold, Ioanna, Heiman, Mark L., Kautzky-Willer, Alexandra ORCID: 0000-0002-3520-4105, Klein, Sabra L., Murphy, Anne, Regitz-Zagrosek, Vera, Reue, Karen and Rubin, Joshua B. (2021). Sex- and Gender-Based Pharmacological Response to Drugss. Pharmacol. Rev., 73 (2). S. 730 - 763. BETHESDA: AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS. ISSN 1521-0081

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Abstract

In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences of biologic sex produces different in vivo environments for male and female cells. We dissect how these influences of sex modify the pharmacokinetics and pharmacodynamics of multiple drugs and provide examples for common drugs acting on specific organ systems. We also discuss how gender of physicians and patients may influence the therapeutic response to drugs. We aim to highlight sex as a genetic modifier of the pharmacological response to drugs, which should be considered as a necessary step toward precision medicine that will benefit men and women. Significance Statement-This study discusses the influences of biologic sex on the pharmacokinetics and pharmacodynamics of drugs and provides examples for common drugs acting on specific organ systems. This study also discusses how gender of physicians and patients influence the therapeutic response to drugs.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mauvais-Jarvis, FranckUNSPECIFIEDorcid.org/0000-0002-0874-0754UNSPECIFIED
Berthold, Heiner K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campesi, IlariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carrero, Juan-JesusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dakal, SantoshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franconi, FlaviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gouni-Berthold, IoannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heiman, Mark L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kautzky-Willer, AlexandraUNSPECIFIEDorcid.org/0000-0002-3520-4105UNSPECIFIED
Klein, Sabra L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murphy, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regitz-Zagrosek, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reue, KarenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rubin, Joshua B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-604361
DOI: 10.1124/pharmrev.120.000206
Journal or Publication Title: Pharmacol. Rev.
Volume: 73
Number: 2
Page Range: S. 730 - 763
Date: 2021
Publisher: AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
Place of Publication: BETHESDA
ISSN: 1521-0081
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INACTIVATED INFLUENZA VACCINE; RENIN-ANGIOTENSIN SYSTEM; VENTROLATERAL PERIAQUEDUCTAL GRAY; CARDIAC-INSUFFICIENCY BISOPROLOL; RANDOMIZED INTERVENTION TRIAL; BACTERIAL BETA-GLUCURONIDASE; MORPHINE-INDUCED ANALGESIA; CONGESTIVE-HEART-FAILURE; CRITICALLY-ILL PATIENTS; RISK-FACTOR CONTROLMultiple languages
Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60436

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